Identification and regulation of differentiation In bone marrow -derived vascular progenitor cells

我们认为骨髓来源的祖细胞可能参与了血管疾病的发病机制。另一方面，据报道，在其他实验系统中，骨髓细胞并不实质性地参与血管重构。在这项研究中，三种不同类型的机械血管损伤发生在同一只小鼠身上，该小鼠的骨髓与GFP或LacZ小鼠的骨髓进行了重组。众所周知，所有损伤都会导致平滑肌细胞(SMC)增殖。在钢丝介导的血管内损伤后4周，大量的新生细胞和中层细胞从骨髓中分化出来。相反，在血管周围袖带置换引起的损伤中，标记阳性细胞很少检测到。结扎颈总动脉后新生内膜内仅有少量骨髓源性细胞。这些结果表明，内膜细胞的来源是不同的，并且骨髓来源的细胞在新生内膜增生中的作用取决于模型的类型。

We have suggested that bone marrow-derived progenitor cells may contribute to the pathogenesis of vascular diseases. On the other hand, It was reported that bone marrow cells do not participate substantially in vascular remodeling in other experimental systems. in this study, three distinct types of mechanical vascular injuries were induced in the same mouse whose bone marrow had been reconstituted with that of GFP or LacZ mice. All injuries are known to cause smooth muscle cell (SMC) hyperplasia. At 4 weeks after wire-mediated endovascular injury, a significant number of the neointlmal and medial cells derived from bone marrow. In contrast, marker-positive cells were seldom detected in the lesion induced by perivascular cuff replacement. There were only a few bone marrow-derived cells in the neointima after ligation of the common carotid artery. These results indicate that the origin of Intimal cells is diverse and that contribution of bone marrow-derived cells to neointlmal hyperpiasia depends on the type of model.