Development of novel therapy for atherosclerosis using adipose tissue-derived stem cells
Development of novel therapy for atherosclerosis using adipose tissue-derived stem cells
批准号:
22590822
负责人:
HIRATA Yasunobu
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
脂肪组织源性干细胞(ASC)可以分化为包括血管细胞在内的多种细胞。在本研究中,我们发现ASC能够被引入血管内皮细胞,并且ASC抑制血管损伤引起的新内膜形成。ASC还能改善海绵体功能。这些影响是由ASC的旁分泌作用引起的。
英文摘要
Adipose tissue-derived stem cells (ASC) can differentiate to various kinds of cells including vascular cells. In the present studies, we showed that ASC were able to be introduced to vascular endothelial cells, and that ASC suppressed neointimal formation caused by vessel injury. ASC also improved the cavernous function. These effects were caused by paracrine effects of ASC.
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DOI:
--
发表时间:
2010
期刊:
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影响因子:
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作者:
[Oba S, Kumano S, Suzuki E, Nishimatsu H, Takahashi M, Takamori H, Kasuya M, Ogawa Y, Sato K, Kimura K, Homma Y, Hirata Y, Fujita T., Hirata Y, Sahara M]
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发表时间:
2012
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发表时间:
2011
期刊:
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[永井良三, 山下尋史, 絹川弘一郎, 今井靖, 波多野将, 八尾厚史, 宇野漢成, 竹中克, 平田恭信]
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DOI:
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发表时间:
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发表时间:
2012
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[田中知明, 松岡優, 須谷顕尚, 長井良昭, 小山信之, 宮沢仁志, 金澤實, 清水禎彦, 池淵研二, 森田智視, 小林国彦, 萩原弘一, 小原克彦]
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共 65 条
Studies on visualization of arteriosclerotic lesion using vascular cell-derived vasoactive substances
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批准号:16390217
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
-
财政年份:2004
-
负责人:HIRATA Yasunobu
-
依托单位:
Identification and regulation of differentiation In bone marrow -derived vascular progenitor cells
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批准号:13557061
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.42万
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财政年份:2001
-
负责人:HIRATA Yasunobu
-
依托单位:
Role of apoptosis of vascular endothelial cells In atherosclerosis
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批准号:13470141
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.1万
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财政年份:2001
-
负责人:HIRATA Yasunobu
-
依托单位:
Research on mechanisms for vascular action of adrenomedullin
-
批准号:10218202
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$42.05万
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财政年份:1998
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负责人:HIRATA Yasunobu
-
依托单位:
Establishment of nitric oxide measurement in exhaled air and its clinical application.
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批准号:09670700
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.79万
-
财政年份:1997
-
负责人:HIRATA Yasunobu
-
依托单位:
Development of sensitve assay of NO and its clinical application
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批准号:07557055
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$6.98万
-
财政年份:1995
-
负责人:HIRATA Yasunobu
-
依托单位:
Studies on mechanisms of atrial natriuretic peptide secretion
-
批准号:61570405
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.09万
-
财政年份:1986
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负责人:HIRATA Yasunobu
-
依托单位:
海外基金