The research for the ethnical differences of the susceptibility genes of rheumatic diseases in East Asia.

本研究的目的是基于共同或不同的遗传因素，阐明风湿病的遗传背景，并收集样本。以下是与韩国、台湾和泰国的海外合作者达成的协议。1.RA、SSc、白塞病(BD)、Werner综合征(WS)是本病的首选治疗对象。2.识别靶基因和包括CARF在内的自身抗体。3.批准了通用临床病历。4.对样品和分析结果的共识得到了认可。5.各国对本国的知情同意负有责任。6.开发了基于网络系统的数据库表单(ASCA)。7.已在所有国家收集了样本。在日本，从对照、RA和BD收集样本的工作进展顺利。8.对照组的人类白细胞抗原-DR、B、CTLA-4分析基本完成，类风湿性关节炎和脑梗死组的分析已基本完成。我们没有发现RA和CTLA-4之间存在关联。9.有DRB1^*0405的RA患者血清肿瘤坏死因子^*2显著升高。TnFa11和b4随*0405略有升高。基础试验是在EST-1、GPIIIa、MBP和TLR4上进行的。对于包括TAP在内的几个遗传因素，已经与国外的数据进行了比较。10.利用模型数据对EH程序进行了验证，并指出了存在的问题。开发了通用分析系统。11.与韩国的合作是通过交换目标基因的分析信息和数据进行的。与台湾和泰国在分析人类白细胞抗原、CTLA-4、肿瘤坏死因子、CARF等方面进行了合作。在本课题已建成研究基地的基础上，从2005年起提出新的研究项目，即本研究的更新项目。

The purpose of this research is to clarify the genetic background of the rheumatic diseases based on the common or different genetic factor, and to collect the samples. The followings are agreements with oversea collaborators in Korea, Taiwan and Thai. 1.RA, SSc, Behcet disease (BD), Werner syndrome (WS) are first target diseases. 2.The target genes and auto-antibodies including CARF were recognized. 3.The common clinical chart was approved. 4.The consensus were approved on the samples and the analytical-results. 5.Each country is responsible for Informed Consent of the country. 6.In this research the Data-Base-form (ASCA) was developed on the network-system. 7.Samples have been collected in all countries. In Japan the collection of samples from control, RA and BD have gone satisfactorily. 8.The analyses of HLA-DR, HLA-B and CTLA-4 were almost completed in control and have been gone in RA and BD. We have found no association between RA and CTLA-4. 9.The TNF^*2 increased significantly in RA with DRB1^*0405 independently. TNFa11 and b4 increased slightly accompanied with the *0405. The basic trials were done on EST-1, GPIIIa, MBP and TLR4. For several genetic factors including TAP, the comparisons with data from foreign countries have been done. 10.Using the model-data, the EH program was verified and the problems have been shown. The analytical system of common-use has been developed. 11.The collaborations with Korea have been done by exchange informations of analyses and data of the target genes. The collaborations with Taiwan and Thai have been done on analyses of HLA, CTLA-4, TNF, CARF, et al. We are going to forward the new research project from 2005, that is the renewal project of this research, based on the research-bases have been constructed by this project.