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The research for the ethnical differences of the susceptibility genes of rheumatic diseases in East Asia.

东亚地区风湿性疾病易感基因的种族差异研究。

基本信息

批准号：
14406018
负责人：
TAKEUCHI Fujio
金额：
$ 7.68万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14406018/
关键词：
rheumatoid arthritis scleroderma Behcet Disease Werner syndrome genetic factor East Asia ethnical difference rheumatic disease SSC 台湾韓国遺伝子

项目摘要

The purpose of this research is to clarify the genetic background of the rheumatic diseases based on the common or different genetic factor, and to collect the samples. The followings are agreements with oversea collaborators in Korea, Taiwan and Thai. 1.RA, SSc, Behcet disease (BD), Werner syndrome (WS) are first target diseases. 2.The target genes and auto-antibodies including CARF were recognized. 3.The common clinical chart was approved. 4.The consensus were approved on the samples and the analytical-results. 5.Each country is responsible for Informed Consent of the country. 6.In this research the Data-Base-form (ASCA) was developed on the network-system. 7.Samples have been collected in all countries. In Japan the collection of samples from control, RA and BD have gone satisfactorily. 8.The analyses of HLA-DR, HLA-B and CTLA-4 were almost completed in control and have been gone in RA and BD. We have found no association between RA and CTLA-4. 9.The TNF^*2 increased significantly in RA with DRB1^*0405 independently. TNFa11 and b4 increased slightly accompanied with the *0405. The basic trials were done on EST-1, GPIIIa, MBP and TLR4. For several genetic factors including TAP, the comparisons with data from foreign countries have been done. 10.Using the model-data, the EH program was verified and the problems have been shown. The analytical system of common-use has been developed. 11.The collaborations with Korea have been done by exchange informations of analyses and data of the target genes. The collaborations with Taiwan and Thai have been done on analyses of HLA, CTLA-4, TNF, CARF, et al. We are going to forward the new research project from 2005, that is the renewal project of this research, based on the research-bases have been constructed by this project.

本研究的目的是根据风湿性疾病的共同或不同遗传因素，阐明风湿性疾病的遗传背景，并收集样本。以下是与韩国、台湾和泰国的海外合作者签订的协议。1.RA、SSc、Behcet病（BD）、Werner综合征（WS）为首选靶疾病。2.目的基因和自身抗体包括CARF被识别。3.批准了通用临床图表。4.对样品和分析结果达成共识。5.每个国家都对本国的知情同意负责。6.本研究在网络系统上开发了数据库表单（ASCA）。7.已在所有国家收集了样本。在日本，从对照、RA和BD采集的样品令人满意。8. HLA-DR、HLA-B和CTLA-4的分析在对照组已基本完成，在RA和BD组已完成。我们没有发现RA和CTLA-4之间的关联。9. TNF^*2在RA中与DRB 1 ^*0405无关地显著升高。TNFa 11和b4随着 *0405的增加而略有增加。对EST-1、GPIIIa、MBP和TLR 4进行了基础试验。对于包括TAP在内的几个遗传因素，与国外资料进行了比较。10.利用模型数据对EH程序进行了验证，并指出了存在的问题。开发了通用分析系统。11.与韩国的合作是通过交换目的基因的分析和数据信息来完成的。与台湾、泰国等国家和地区进行了HLA、CTLA-4、TNF、CARF等的研究合作。在此基础上，我们将于2005年提出新的研究项目，即本研究的更新项目。