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Association of HLA-DR and TAP genes with PSS in Koreans.-the basic trial

Association of HLA-DR and TAP genes with PSS in Koreans.-the basic trial
韩国人 HLA-DR 和 TAP 基因与 PSS 的关联——基础试验
批准号:
07044317
负责人:
TAKEUCHI Fujio
金额:
$0.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for International Scientific Research.
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 --

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中文摘要
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英文摘要
The contribution of genetic factors to PSS is still unclear. We started the co-work on TAP gene in Korean PSS with Seoul University in Korea. In this research period, the purpose of research is to establish the basical research conditions for co-work. For the purpose, we examined Japanese PSS to establish the research method and presented the research information to Korean researcher. TAP1 and TAP2 typing was carried out in 92 Japanese PSS patients and 95 normal subjects by PCR-RFLP method. HLA-DR typing and HLA DRB1**15, **16 and **08 genotyping were carried out by PCR method and PCR-SSCP method, respectively.For co-work, we established the universal database between Korean and Japanese. In PSS with diffuse scleroderma alleles frequencies of TAP1A and TAP2A were significantly increased (100%, p<0.005 ; 80.0%, p<0.001, respectively). In PSS with antitopisomerase I antibody (a-Scl-70) TAP1A and TAP2A alleles were also increased (93.2%, p=NS ; 63.6%, p<0.05). To the contrary, TAP1B allel … More e was significantly decreased in diffuse scleroderma (0%, p<0.005) and PSS with a-SCL-70 (4.5%, p<0.05). TAP2B was also decreased in diffuse scleroderma (12.5%, p<0.01). The examination of DR and DRB1 showed the significant increase in DRB1**1502 in diffuse scleroderma and a-Scl-70 positive PSS,as our previous study. Association analysis among TAP1A,TAP2A and DRB1**1502 indicated increases in TAP1A and TAP2A were not primary but reflect of an increase in HLA DRB1**1502 in Japanese PSS with diffuse scleroderma and PSS with a-Scl-70.The conclusion, however, was not concorded with Caucasians, so that informations from PSS in Korean were very important for clarify the genetic pathogenesis of PSS.In this study, Korean samples including Korean normal has been ccllected already, and several samples were tested, preliminary, in Seoul University. Additionally, clinical features has also been studied using universal protocol, above mentioned. TAP and DR genes of Korean PSS will be clarified after next research period. Less
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会议论文
Takeuchi Fujio et al.: "Association of TAP1 and TAP2 with RA in Japanese." (to be submitted).
Takeuchi Fujio 等人:“TAP1 和 TAP2 与日语中 RA 的关联。”
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Pattanakitsakul S,Takeuchi Fujio et al.: "A novel new TAP2 gene RFLP observed in Japanese." Tissue Antigens. (in press). (1996)
Pattanakitsakul S、Takeuchi Fujio 等人:“在日语中观察到的一种新的 TAP2 基因 RFLP。”
DOI: --
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作者: []
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The research on the clinical characters of malignant neoplasm andthe origin of the causative-gene mutation in Werner's syndrome.
  • 批准号:
    21590755
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.16万
  • 财政年份:
    2009
  • 负责人:
    TAKEUCHI Fujio
  • 依托单位:
The genetic research for the ethnical differences of the susceptibility genes of rheumatic diseases in East Asia
  • 批准号:
    17406026
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $9.57万
  • 财政年份:
    2005
  • 负责人:
    TAKEUCHI Fujio
  • 依托单位:
The research for the ethnical differences of the susceptibility genes of rheumatic diseases in East Asia.
  • 批准号:
    14406018
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $7.68万
  • 财政年份:
    2002
  • 负责人:
    TAKEUCHI Fujio
  • 依托单位:
The research for the genetic factors of rheumatoid arthritis using the methods applying the polymorphism in microsatellites and the single nucleotide polymorphism
  • 批准号:
    12670417
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.92万
  • 财政年份:
    2000
  • 负责人:
    TAKEUCHI Fujio
  • 依托单位:
海外基金