Dynamics of lipid metabolism in ferroptosis

铁死亡中脂质代谢的动态

• 批准号: 461705208
• 负责人: Professor Dr. Christoph Thiele
• 金额: --
• 依托单位: Abteilung Biochemie & Zellbiologie der Lipide
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/461705208?language=en
• 关键词: Dynamics; lipid; metabolism; ferroptosis

Ferroptosis is a type of cell death that is caused by excessive reaction of cellular compounds with oxygen. Lipids that build the cell membranes are strongly affected, in particular if they contain polyunsaturated fatty acids. We want to follow these events, called lipid peroxidation, with novel technology. Our group has developed a method, using labeled fatty acids, to measure lipid metabolism with very high sensitivity. We want to use this method to show the time and the place of lipid peroxidation and the identity of the lipids affected. These measurements would be the first to follow lipid metabolism in ferroptosis with time resolution. We expect to obtain information that would contribute to the development of cancer treatments based on ferroptotic cell death.

铁下垂是一种由细胞化合物与氧过度反应引起的细胞死亡。构建细胞膜的脂质受到强烈影响，特别是如果它们含有多不饱和脂肪酸。我们想用新技术跟踪这些事件，称为脂质过氧化。我们小组开发了一种方法，使用标记脂肪酸，以非常高的灵敏度测量脂质代谢。我们想用这种方法来显示脂质过氧化的时间和地点以及受影响的脂质的身份。这些测量将是第一个以时间分辨率跟踪铁下垂的脂质代谢。我们期望获得的信息，将有助于发展基于嗜铁性细胞死亡的癌症治疗。