权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Fundamental verification to establish evidences among pulmonary rehabilitation.

为肺康复奠定证据的基础验证。

基本信息

批准号：
15300192
负责人：
KUROSAWA Hajime
金额：
$ 10.82万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15300192/
关键词：
pursed-lip breathing electron-beam CT respiratory muscle training dyspnea tissue oxygen saturation oxygen consumption of respiratory muscles body plethysmography dead space loading system 呼吸リハビリテーション理学療法鼻咽腔閉鎖呼吸抵抗呼吸筋組織酸素飽和度慢性

项目摘要

1)To examine the effects of Pursed hp breathing (PLB) on broncho-dilation and improvement of respiratory efficiency by changing respiratory pattern which have been historically assumed, ventilatory mechanics was measured in 10 healthy subjects during PLB. We reported respiratory impedance and nasopharyngeal closure during PLB at ATS meeting 2004 and submitted for publication. Further, the measurements were also performed in the patients with COPD. The results showed various changes during PLB, which will be reported at Japanese Society for Respiratory Care 2005 and American College of Chest Physicians 2005, and will be submitted. EEG study during PLB were planned to examine the effects on dyspnea sensation in healthy subjects and patients with COPD. We almost finished to obtain the data to performm frequency analysis of EEG alfa-wave. Currently, the analysis is undergoing. The data concerning R-R variation in ECG is also being studied during PLB, but not finished, yet.2)We newly develo … More ped "Dead space loading system" to measure oxygen consumption of respiratory muscle before and after chest physiotherapy This system allows to measure the oxygen consumption without influence of functional residual capacity, and is suited for patients with COPD. A patent was already applied for the system. The preliminary studies were done, and the measurement will be started in the patients with COPD before and after chest physiotherapy.3)We tried to study tissue oxygen saturation in intercostals muscles to investigate the optimal load for respiratory muscle training. However, because of technical difficulties, we decided to change the target of the assessment to respiratory accessory muscles and to continue to do experiments.4)It became impossible to take image of the lung during PLB using electron-beam CT because of the problem in the Hospital. The preliminary images were already published in New England Journal of Medicine. Joint projects to study bronch-dailating effects during PLB using electron-beam CT is under processing with Shiga Medical University. Less

1）为探讨推注式hp呼吸（PLB）对支气管扩张和呼吸效率的影响，对10名健康受试者进行了推注式hp呼吸（PLB）时支气管扩张和呼吸效率的测定。我们在2004年ATS会议上报告了PLB期间的呼吸阻抗和鼻咽闭合，并提交发表。此外，还在COPD患者中进行了测量。结果显示PLB期间的各种变化，将在2005年日本呼吸护理学会和2005年美国胸科医师学会上报告并提交。计划在PLB期间进行EEG研究，以检查对健康受试者和COPD患者呼吸困难感觉的影响。基本完成了对脑电α波进行频率分析的数据采集。目前，分析正在进行中。关于PLB中心电图R-R变异的数据也正在研究中，但尚未完成。2）我们新开发了一种新的心电图R-R变异的检测方法， ...更多信息使用“死腔负荷系统”测量胸部物理治疗前后呼吸肌的耗氧量该系统可以测量耗氧量，而不影响功能残气量，适用于COPD患者。该系统已经申请了专利。对COPD患者胸部物理治疗前后的血氧饱和度进行了初步研究，并将在此基础上开展COPD患者胸部物理治疗前后的血氧饱和度测定。然而，由于技术上的困难，我们决定将评估的目标改为呼吸辅助肌，并继续进行实验。4）由于医院的问题，在PLB期间无法使用电子束CT拍摄肺部图像。初步的图像已经发表在新英格兰医学杂志上。正在与滋贺医科大学合作，研究使用电子束CT在PLB期间对支气管的影响。少