Research on the Thermo-sensitive Phase Separable Solutions and Their Applications for Solution-phase Organic Reactions and Separations

热敏相分离溶液及其在溶液相有机反应和分离中的应用研究

• 批准号: 15350053
• 负责人: CHIBA Kazuhiro
• 金额: $ 8.19万
• 依托单位: National University Corporation Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15350053/
• 关键词: Peptide; Biphasic System; Thermal Property; Organic Synthesis; Cyclohexane; Separation; ペプチド合成; 液相合成; 相溶; 二相系; コンビナトリアル合成; オリゴペプチド; 分離精製法

A new thermomorphic organic solution system was introduced to accomplish wide variety of liquid-phase combinatorial chemistry. It was found that the combination of organic solutions composed of cycloalkanes and typical polar organic solvents formed phase-separable homogeneous solutions at ambient temperature. In this case, cycloalkanes effectively worked for the thermally sensitive phase-transformation. The cycloalkane phase separable systems were widely applied for several kind of liquid-phase combinatorial chemistry.

引入了一种新的热形态有机溶液系统来完成各种液相组合化学。研究发现，由环烷烃组成的有机溶液与典型极性有机溶剂的组合在环境温度下形成可相分离的均匀溶液。在这种情况下，环烷烃有效地促进了热敏相变。环烷烃相分离体系广泛应用于多种液相组合化学。

项目成果

Calcineurin inhibitors block dorsal-side signaling that affects late-stage development of the hearte during Xenopus embryogenesis

钙调神经磷酸酶抑制剂阻断影响非洲爪蟾胚胎发生过程中心脏后期发育的背侧信号传导

• 发表时间: 2004
• 期刊: Development Growth & Differentiation 46
• 作者: Yinggung Wu;M.Tabata;Yoko Yoshida
• 通讯作者: Yoko Yoshida

Cycloalkane-Based Phase-Separable Liquid-Phase Peptide Synthesis

基于环烷烃的相分离液相肽合成

• 发表时间: 2005
• 期刊: Peptide Science (印刷中)
• 作者: I.-W.Hwang;T.K.Ahn;D.M.Ko;D.Kim;T.Kamada;T.Nakamura;A.Tsuda;A.Osuka;Kazuhiro Chiba
• 通讯作者: Kazuhiro Chiba

Yoko Yoshida, Shokaku Kim, Kazuhiro Chiba, Shinya Kawai, Hiroyuki Tachikawa, Nobuhiro Takahashi: "Calcineurin inhibitors block dorsal-side signaling that affects late-stage development of the heart, kidney, liver, gut, and somitic tissue during Xenopus em

Yoko Yoshida、Shokaku Kim、Kazuhiro Chiba、Shinya Kawai、Hiroyuki Tachikawa、Nobuhiro Takahashi：“钙调神经磷酸酶抑制剂阻断背侧信号传导，影响非洲爪蟾发育过程中心脏、肾脏、肝脏、肠道和体细胞组织的后期发育。

Synthesis and anti-barnacle activities of novel 3-isocyanotheonellin analogues

新型3-异氰酸酯类似物的合成及其抗藤壶活性

• 发表时间: 2004
• 期刊: Biofouling 20
• 作者: M.Goto;K.Otsuka;X.Chen;Y.Tao;M.Oyama;Kitano Yoshikazu
• 通讯作者: Kitano Yoshikazu

Calcineurin inhibitors block dorsal-side signaling that affects late-stage development of the heart, kidney, liver, gut, and somitic tissue during Xenopus embryogenesis

钙调神经磷酸酶抑制剂阻断背侧信号传导，影响非洲爪蟾胚胎发生过程中心脏、肾脏、肝脏、肠道和体细胞组织的后期发育

• 发表时间: 2004
• 期刊: Development Growth & Differentiation 46
• 作者: Yoko Yoshida;Shokaku Kim;Kazuhiro Chiba;Shinya Kawai;Hiroyuki Tachikawa;Nobuhiro Takahashi
• 通讯作者: Nobuhiro Takahashi