Basic research on mechanism of lumbar disc degeneration and ne w development of treatment

腰椎间盘退变机制基础研究及治疗新进展

• 批准号: 22591642
• 负责人: CHIBA Kazuhiro
• 金额: $ 2.91万
• 依托单位: Kitasato University (2011-2012)Keio University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591642/
• 关键词: 運動器; 脊椎; 椎間板; 退行変性; 遺伝子

Crosstalks between ERa/GRIP1 and TGF -b/MKK6/p38 MAPK pathway have protective roles on cartilage metabolism via regulating the extracellular matrices expression.PHD3 controls TNF-α activity by modulating NF-κB signaling. When PHD3 is silenced, there is a significant decrease in TNF -α-induced expression of catabolic markers that include ADAMTS5, syndecan4, MMP13, and at the same time, there is restoration of aggrecan and collagen type II expression. In vivo study, there was a significant positive correlation between the Cobb angle and CPII in degenerative lumbar scoliosis. The results suggest degenerative lumbar scoliosis patients have higher levels of type II collagen synthesis and degradation. These findings may lead to the development of a novel therapeutic approach for cartilage degeneration

ERa/GRIP1与TGF -b/MKK6/p38 MAPK通路之间的串扰通过调节细胞外基质的表达对软骨代谢具有保护作用。PHD3通过调节NF-κB信号传导控制TNF-α活性。当PHD3被沉默时，TNF -α-诱导的ADAMTS5、syndecan4、MMP13等分解代谢标志物的表达显著降低，同时聚集蛋白和II型胶原的表达恢复。在体内研究中，Cobb角与退行性腰椎侧凸的CPII呈正相关。结果表明退行性腰椎侧凸患者有较高水平的II型胶原合成和降解。这些发现可能会导致发展一种新的治疗方法的软骨变性

项目成果

Cartilage biomarkers in degenerative lumbar scoliosis

退行性腰椎侧凸的软骨生物标志物

• 发表时间: 2012
• 作者: S Ymamoto;et al.;山田宏;Hosogane N
• 通讯作者: Hosogane N

Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus

• DOI: 10.1007/s00776-011-0135-2
• 发表时间: 2011-11-01
• 期刊: JOURNAL OF ORTHOPAEDIC SCIENCE
• 影响因子: 1.7
• 作者: Cui, Guanyu;Watanabe, Kota;Matsumoto, Morio
• 通讯作者: Matsumoto, Morio

診断と治療 主訴から診断へ

诊断与治疗 从主诉到诊断

• 发表时间: 2013
• 作者: 大島正史;徳橋泰明;鶴田尚志;網代泰充;上井浩;辻崇
• 通讯作者: 辻崇

Serum cartilage metabolites as biomarkers of degenerative lumbar scoliosis

• DOI: 10.1002/jor.22067
• 发表时间: 2012-08-01
• 期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
• 影响因子: 2.8
• 作者: Hosogane, Naobumi;Watanabe, Kota;Matsumoto, Morio
• 通讯作者: Matsumoto, Morio

運動器の痛みを取る・やわらげる

缓解和减轻肌肉骨骼器官的疼痛

• 发表时间: 2012
• 作者: 辻崇;千葉一裕
• 通讯作者: 千葉一裕