Genetic analysis of neonatal growth retardation, a lethal syndrome with multiple genes involving X-and Y-linked ones

F_1-Dh/+雄虫，即DDD品系雌虫与DH-Dh/+品系雄虫的杂交后代，大多数雄虫在新生期死亡。受影响的F_1-Dh/+雄性动物表现出典型的生长迟缓症状，并伴有排尿和排便问题。这是由于直肠膀胱瘘形成之间的直肠和膀胱与imperialanus。在DH-Dh/+雌性和DDD雄性之间的相互杂交中不发生致死表型。遗传作图分析的基础上的致死性的基因座揭示，致死性是一个协同作用的结果，三个独立的基因座之间，即DH等位基因在Dh基因座上的Chr 1，DDD等位基因在Grdhq 1基因座上的X Chr，和一个假定的Y-连锁的基因座在一些近交系。通过建立Y染色体同源株，证实了Y染色体连锁基因的定型。在研究过程中，我注意到Dh对雄性育性有影响，并初步得到了Dh可能与多个Y连锁基因相互作用的结果。

Most F_1-Dh/+ males, crosses between inbred DDD strain females and DH-Dh/+ strain males, die during the neonatal period. Affected F_1-Dh/+ males exhibit a typical symptom of growth retardation, with problems of urination and defecation. This is caused by a rectovesical fistula formed between the rectum and the urinary bladder in conjunction with an imperforate anus. The lethal phenotype does not occur in the reciprocal cross between DH-Dh/+ females and DDD males. Genetic mapping analysis of the loci underlying the lethality has revealed that the lethality is a consequence of synergism among three independent gene loci; that is, the DH allele at Dh locus on Chr 1, the DDD allele at the Grdhq1 locus on the X Chr, and a putative Y-linked locus in some inbred strains. By establishing Y chromosome consomic strains, I proved the commitment of Y-linked gene(s). During the course of the study, I noticed that Dh has effects on male fertility, and obtained some preliminary results that Dh may interacts with more than one Y-linked genes.