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Research on the neural process relating to biofeedback by fMRI and MEG measurement

通过功能磁共振成像和脑磁图测量研究生物反馈相关的神经过程

基本信息

批准号：
15500331
负责人：
NISHIMURA Chiaki
金额：
$ 2.11万
依托单位：
Toho University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500331/
关键词：
biofeedback fMRI state alteration of consciousness autonomic activity neural model learning autobiographical memory MEG fMR I 高次脳機能意識・無意識モデル脳内過程心拍ゆらぎ順応記憶

项目摘要

Biofeedback is considered as a learning process of mind-body interaction relating to both supra- and sub-consciousness. To investigate the neural process relating to biofeedback, we conducted fMRI and MEG measurements from four viewpoints : (1)the state alteration of consciousness, (2)familiarization in information acquisition, (3)memory and imagery in mediation, and (4)neural activity in central nervous system to control autonomic system. In experiment (1), neural activity in bilateral prefrontal region was closely related to the alteration process. In experiment (2), auditory familiarization was correlated with the area change of active auditory region. In experiment (3), images associated with the autobiographical memory were shown to be effective in assisting the learning process in biofeedback. And in experiment (4), activity in autonomic nervous system was accompanied by activities in the limbic system and the ganglia as well as some cortical areas. Referring the results a mathematical model was proposed in which a learning system on the conscious level learns characteristics of a subconscious regulation system corresponding to the target biological function. When the learning converges, the learning system itself becomes an inverse system of the regulation system. Then, if a regulation command is put to the learning system on the conscious level, it drives the regulation system strictly following the command without the outer feedback pathway, which enables voluntary control of the biological function. The model well explains characteristics of biofeedback: addition of outer informational pathway in the learning process, a series of self-learning referring it,. and eventual acquisition of ability to voluntarily control the target biological function without the aid of the outer feedback pathway.

生物反馈被认为是一种与超意识和潜意识有关的身心互动的学习过程。为了研究与生物反馈有关的神经过程，我们从四个角度进行了fMRI和MEG测量：（1）意识的状态改变，（2）信息获取中的熟悉，（3）中介中的记忆和想象，以及（4）中枢神经系统控制自主神经系统的神经活动。在实验（1）中，双侧前额叶的神经活动与改变过程密切相关。实验（2）中，听觉熟悉程度与听觉活跃区面积变化相关。在实验（3）中，与自传体记忆相关联的图像被证明是有效的，以帮助学习过程中的生物反馈。在实验（4）中，自主神经系统的活动伴随着边缘系统和神经节以及某些皮层区域的活动。参考结果，提出了一个数学模型，其中在意识水平上的学习系统学习与目标生物功能相对应的潜意识调节系统的特征。当学习收敛时，学习系统本身成为调节系统的逆系统。然后，如果在意识层面上向学习系统发出调节命令，它会驱动调节系统严格遵循命令，而无需外部反馈路径，这使得能够对生物功能进行自愿控制。该模型很好地解释了生物反馈的特点：在学习过程中加入外部信息通路，并在此基础上进行一系列的自我学习。并最终获得自主控制目标生物功能的能力而无需外部反馈途径的帮助。