权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Difference in carotid artery stiffness between men and women as a heart disease risk factor

男性和女性颈动脉僵硬度作为心脏病危险因素的差异

基本信息

批准号：
15500348
负责人：
CHANG Dehua
金额：
$ 2.24万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

Arterial stiffness is considered to be an independent risk factor for cardiovascular disease. Several previous studies have reported gender-related differences in large arterial stiffness. It is necessary to measure stiffness of various arteries in various populations by a reliable method. Using an echo-tracking system, we measured instantaneous diameter change of the carotid artery in 175 normal volunteers (99men, 76women, aged 20 to 77 years). In the supine position, and calculated stiffness parameter β and pressure strain elastic modulus Ep. β and relation of age with Ep and relation of age were analyzed by gender. Both in women and men, β were linearly related to age with high goodness-of-fit (r^2) values and narrow 95% confidence intervals. There were no significant differences in the slope and Y-intercept of the regression line. Ep was linearly related to age with high goodness-of-fit (r^2) values and narrow 95% confidence intervals the slope and Y-intercept of the regression line of men was significantly higher than women (p<0.05). β was closely related to age and there was no difference between women and men in our study group. Ep depends on blood pressure, and there was a difference. We should take account of the dependence of an index of stiffness on blood pressure when analyzing the difference in arterial stiffness between women and men.

动脉僵硬被认为是心血管疾病的独立危险因素。之前的几项研究报告了大动脉僵硬的性别差异。因此，有必要对不同人群的各种动脉硬度进行可靠的测量。我们用回声跟踪系统测量了175名正常志愿者(男99名，女76名，年龄20-77岁)颈动脉的瞬时内径变化。在仰卧位，计算了刚度参数β和压应变弹性模数Ep。按性别分析β、年龄与EP的关系以及年龄的关系。在女性和男性中，β与年龄呈线性相关，具有较高的拟合度(r^2)值和较窄的95%可信区间。回归线的斜率和Y截距无显著差异。Ep与年龄呈线性相关，拟合度较高(r^2)，95%可信区间较窄，男性回归直线的斜率和Y截距显着高于女性(p&lt；0.05)。β与年龄密切相关，研究组男女之间无差异。EP取决于血压，这是有区别的。在分析男性和女性动脉僵硬的差异时，我们应该考虑到僵硬指数对血压的依赖性。