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Research into the effects of sport activity on platelet and endothelial function and on development of atherosclerosis in children.

研究体育活动对血小板和内皮功能以及儿童动脉粥样硬化发展的影响。

基本信息

批准号：
15500431
负责人：
HORIGOME Hitoshi
金额：
$ 2.37万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500431/
关键词：
sports medicine pediatrics adult disease atherosclerosis platelet function coagulofibrinolysis 動脈硬化症

项目摘要

Introduction : Adult disease, including atherosclerosis, has its origins in childhood. Endothelial and platelet functions are implicated in progression of atherosclerosis. Although weight control is important for prevention of adult disease, changes in endothelial and platelet function due to growth or to exercise have not been clarified. Moreover, effective diet and/or exercise intervention from childhood has not been established. We investigated platelet activity and coagulofibrinolytic proteins that enhance endothelial function in children, adults and patients with cyanotic congenital heart disease (CCHD). We also assessed the effect of weight reduction on these markers.Materials and Method : 1.Plasma levels of soluble P-selectin, beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), protein C and protein S in CCHD patients were measured. 2.Diurnal changes (9:00 am vs 4:00 pm) in plasminogen activator inhibitor-1 (PAI-1) activity and tissue-type plasminogen activator (t-PA) antig … More en levels in CCHD patients were evaluated. 3.Effects of weight reduction on platelet derived microparticles (PMP) released from activated platelets, PAI-1 activity and t-PA antigen were compared between 12-week calorie restricted diet with or without aerobic exercise in obese adults.Results : 1.Plasma levels of P-selectin, beta-TG,PF4 were significantly high, and those of free protein S antigen and protein C activity were significantly low in CCHD patients compared with acyanotic patients. P-selectin and beta-TG correlated positively, and protein S and protein C correlated negatively with hematocrit. 2.Morning increase of PAI-1 activity and t-PA antigen levels was observed in CCHD patients. Plasma levels of t-PA antigen at 9 am and 4 pm were higher in CCHD patients than those in acyanotic patients, and correlated positively with the levels of erythrocytosis. 3.PMP,PAI-1 activity and t-PA antigen values were elevated in obese adults in comparison with non-obese adults, and these three parameters correlated with body mass index (BMI). The intervention significantly reduced PMP,PAI-1 and t-PA antigen levels. There was a significant correlation between percentages of change in PMP values and those in BMI, fat tissue mass.Conclusion : Weight reduction appears to be essential for prevention of adult disease, through improvement of endothelial and platelet functions. There were platelet and coagulofibrinolytic abnormalities in CCHD patients who were exposed to chronic hypoxia. Strenuous exercise would induce transient tissue hypoxia. Establishment of appropriate diet and exercise therapies for age could contribute to prevention of adult disease from childhood. Less

导语：成人疾病，包括动脉粥样硬化，起源于童年。内皮功能和血小板功能与动脉粥样硬化的进展有关。虽然体重控制对于预防成人疾病很重要，但由于生长或运动而导致的内皮和血小板功能的变化还不清楚。此外，还没有建立起有效的儿童饮食和/或运动干预措施。我们研究了儿童、成人和青紫型先天性心脏病(CCHD)患者中增强内皮功能的血小板活性和凝血纤溶蛋白。材料与方法：1.检测慢性心力衰竭患者血浆中可溶性P-选择素、β-血栓球蛋白、血小板第4因子、蛋白C、S蛋白水平。2.纤溶酶原激活物抑制物-1活性和组织型纤溶酶原激活物抗…的日变化(上午9：00与下午4：00)对CCHD患者进行更多的EN水平评估。3.比较12周限热量饮食加有氧运动和不加有氧运动对肥胖成人活化血小板释放的血小板衍生微粒、纤溶酶原激活物-1活性和t-PA抗原的影响。结果：1.慢性心绞痛患者血浆P-选择素、β-甘油三酯、PF4水平明显高于无营养障碍性贫血患者，而游离蛋白S抗原和蛋白C活性显著低于无贫血患者。P-选择素、β-甘油三酯与红细胞压积呈正相关，S蛋白、蛋白C与红细胞压积呈负相关。2.CCHD患者晨间PAI-1活性和t-PA抗原水平升高。CCHD患者上午9点和下午4点的血浆t-PA抗原水平均高于无贫血患者，且与红细胞增多症呈正相关。3.肥胖组PMP、PAI-1活性和t-PA抗原值均高于非肥胖组，并与体重指数(BMI)呈正相关。干预显著降低PMP、PAI-1和t-PA抗原水平。PMP值的变化百分比与BMI、脂肪组织质量之间存在显著的相关性。结论：通过改善内皮和血小板功能，减肥似乎是预防成人疾病的关键。慢性低氧条件下CCHD患者存在血小板和凝血纤溶功能异常。剧烈运动可引起一过性组织缺氧。为老年人制定适当的饮食和运动疗法可有助于从儿童时期起预防成人疾病。较少