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Research into the effects of sport activity on platelet and endothelial function and on development of atherosclerosis in children.

研究体育活动对血小板和内皮功能以及儿童动脉粥样硬化发展的影响。

基本信息

批准号：
15500431
负责人：
HORIGOME Hitoshi
金额：
$ 2.37万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500431/
关键词：
sports medicine pediatrics adult disease atherosclerosis platelet function coagulofibrinolysis 動脈硬化症

项目摘要

Introduction : Adult disease, including atherosclerosis, has its origins in childhood. Endothelial and platelet functions are implicated in progression of atherosclerosis. Although weight control is important for prevention of adult disease, changes in endothelial and platelet function due to growth or to exercise have not been clarified. Moreover, effective diet and/or exercise intervention from childhood has not been established. We investigated platelet activity and coagulofibrinolytic proteins that enhance endothelial function in children, adults and patients with cyanotic congenital heart disease (CCHD). We also assessed the effect of weight reduction on these markers.Materials and Method : 1.Plasma levels of soluble P-selectin, beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), protein C and protein S in CCHD patients were measured. 2.Diurnal changes (9:00 am vs 4:00 pm) in plasminogen activator inhibitor-1 (PAI-1) activity and tissue-type plasminogen activator (t-PA) antig … More en levels in CCHD patients were evaluated. 3.Effects of weight reduction on platelet derived microparticles (PMP) released from activated platelets, PAI-1 activity and t-PA antigen were compared between 12-week calorie restricted diet with or without aerobic exercise in obese adults.Results : 1.Plasma levels of P-selectin, beta-TG,PF4 were significantly high, and those of free protein S antigen and protein C activity were significantly low in CCHD patients compared with acyanotic patients. P-selectin and beta-TG correlated positively, and protein S and protein C correlated negatively with hematocrit. 2.Morning increase of PAI-1 activity and t-PA antigen levels was observed in CCHD patients. Plasma levels of t-PA antigen at 9 am and 4 pm were higher in CCHD patients than those in acyanotic patients, and correlated positively with the levels of erythrocytosis. 3.PMP,PAI-1 activity and t-PA antigen values were elevated in obese adults in comparison with non-obese adults, and these three parameters correlated with body mass index (BMI). The intervention significantly reduced PMP,PAI-1 and t-PA antigen levels. There was a significant correlation between percentages of change in PMP values and those in BMI, fat tissue mass.Conclusion : Weight reduction appears to be essential for prevention of adult disease, through improvement of endothelial and platelet functions. There were platelet and coagulofibrinolytic abnormalities in CCHD patients who were exposed to chronic hypoxia. Strenuous exercise would induce transient tissue hypoxia. Establishment of appropriate diet and exercise therapies for age could contribute to prevention of adult disease from childhood. Less

简介：成人疾病，包括动脉粥样硬化，起源于儿童期。内皮和血小板功能与动脉粥样硬化的进展有关。尽管体重控制对于预防成人疾病很重要，但由于生长或运动引起的内皮和血小板功能的变化尚未明确。此外，尚未建立有效的儿童饮食和/或运动干预措施。我们研究了增强儿童、成人和紫绀型先天性心脏病 (CCHD) 患者内皮功能的血小板活性和凝血纤溶蛋白。我们还评估了体重减轻对这些标志物的影响。材料和方法： 1.测量了CCHD患者的可溶性P-选择素、β-血栓球蛋白(β-TG)、血小板因子4(PF4)、蛋白C和蛋白S的血浆水平。 2.评估 CCHD 患者纤溶酶原激活剂抑制剂-1 (PAI-1) 活性和组织型纤溶酶原激活剂 (t-PA) 抗水平的每日变化（上午 9:00 与下午 4:00）。 3.比较12周热量限制饮食加或不加有氧运动的肥胖成人体重减轻对活化血小板释放的血小板衍生微粒(PMP)、PAI-1活性和t-PA抗原的影响。结果： 1.CCHD患者血浆P-选择素、β-TG、PF4水平显着升高，游离蛋白S抗原和蛋白C活性显着降低与紫绀患者。 P-选择素和β-TG与血细胞比容呈正相关，蛋白S和蛋白C与血细胞比容呈负相关。 2.CCHD患者早晨PAI-1活性和t-PA抗原水平升高。 CCHD患者上午9点和下午4点的血浆t-PA抗原水平高于紫绀患者，并且与红细胞增多水平呈正相关。 3.与非肥胖成人相比，肥胖成人的PMP、PAI-1活性和t-PA抗原值升高，且这三个参数与体重指数（BMI）相关。干预措施显着降低了 PMP、PAI-1 和 t-PA 抗原水平。 PMP 值的变化百分比与 BMI、脂肪组织质量之间存在显着相关性。结论：通过改善内皮和血小板功能，减轻体重似乎对于预防成人疾病至关重要。慢性缺氧的 CCHD 患者存在血小板和凝血纤溶异常。剧烈运动会引起短暂的组织缺氧。制定适合年龄的饮食和运动疗法可能有助于从儿童时期预防成人疾病。较少的