Mechanism of the prevention of the arteriosclerosis by exercise : Focused on the oxidative stress protective mechanism

本研究旨在从氧应激的角度探讨有氧运动对动脉硬化预防作用的机制及其保护机制。本研究从氧应激的角度探讨有氧运动对动脉硬化预防的作用机制及其保护机制。结果如下：1。由于生活方式的改变，氧化应激对身体的影响受到氧化应激防御系统、年龄、血压和BMI的显著影响，有氧运动可以降低氧化应激。干预前的氧化应激状态、尿一氧化氮水平和最大摄氧量与改变生活方式降压效果的差异有关，改变生活方式降压可改善其他心血管风险。生活方式改变后，血压、BMI、脂质代谢、胰岛素抵抗和脂质过氧化得到改善。一氧化氮（NO）的生物有效性被认为在一定程度上有助于通过改变包括运动在内的生活方式来达到降压效果。心血管危险因素的总和（多个危险因素）显示了对每个危险因素严重程度增加的影响以及对心血管危险增加的协同效应。通过参与生活方式改变计划，每个危险因素的严重程度都有所改善，危险因素的数量也有所减少。急性和慢性运动通过刺激核苷酸消毒机制来预防DNA氧化损伤，提示持续有氧运动对DNA氧化损伤的预防有效。

The aim of this study was to investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.In this study, we investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.Results were as follows ;1.As a result of lifestyle modification, it was shown that the oxidative stress to the body was significantly influenced by an oxidative stress defense system, age, blood pressure, and BMI, and aerobic exercise reduced the oxidative stress.2.The state of the oxidative stress before intervention, and urine nitric oxide level and maximum oxygen uptake were involved in the difference in the blood lowering effect by lifestyle modification, and blood pressure reduction by lifestyle modification resulted in improving other cardiovascular risks.3.Blood pressure, BMI, lipid metabolism, insulin resistance, and lipid peroxidation were shown to improve after lifestyle modification. Nitric oxide(NO) biological availability was considered to contribute, in part, to hypotensive effects by lifestyle modification including exercise..4.Summation of cardiovascular risk factors (multiple risk factor) showed the effect on the increase in the severity of each risk factor and the synergistic effect on the increase in an cardiovascular risk. Severity of each risk factor was improved and the number of risk factors were reduced by participation in lifestyle modification program.5.Acute and chronic exercise prevented oxidative DNA damage by stimulating the nucleotide sanitizing mechanism and it was suggested that continuous aerobic exercise is effective for prevention of oxidative DNA damage.