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Mechanism of the prevention of the arteriosclerosis by exercise : Focused on the oxidative stress protective mechanism

运动预防动脉硬化的机制：关注氧化应激保护机制

基本信息

批准号：
15500500
负责人：
IKEDA Masaharu
金额：
$ 2.37万
依托单位：
University of Occupational Health and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The aim of this study was to investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.In this study, we investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.Results were as follows ;1.As a result of lifestyle modification, it was shown that the oxidative stress to the body was significantly influenced by an oxidative stress defense system, age, blood pressure, and BMI, and aerobic exercise reduced the oxidative stress.2.The state of the oxidative stress before intervention, and urine nitric oxide level and maximum oxygen uptake were involved in the difference in the blood lowering effect by lifestyle modification, and blood pressure reduction by lifestyle modification resulted in improving other cardiovascular risks.3.Blood pressure, BMI, lipid metabolism, insulin resistance, and lipid peroxidation were shown to improve after lifestyle modification. Nitric oxide(NO) biological availability was considered to contribute, in part, to hypotensive effects by lifestyle modification including exercise..4.Summation of cardiovascular risk factors (multiple risk factor) showed the effect on the increase in the severity of each risk factor and the synergistic effect on the increase in an cardiovascular risk. Severity of each risk factor was improved and the number of risk factors were reduced by participation in lifestyle modification program.5.Acute and chronic exercise prevented oxidative DNA damage by stimulating the nucleotide sanitizing mechanism and it was suggested that continuous aerobic exercise is effective for prevention of oxidative DNA damage.

本研究旨在从氧应激及其保护机制的角度探讨有氧运动预防动脉硬化的作用机制，结果表明：有氧运动预防动脉硬化的作用机制主要是氧应激及其保护机制; 1.作为生活方式改变的结果，显示对身体的氧化应激受到氧化应激防御系统、年龄、血压和BMI的显著影响，并且有氧运动降低了氧化应激。2.干预前的氧化应激状态，改变生活方式后，血压、BMI、脂代谢、胰岛素抵抗、脂质过氧化反应等指标均得到改善。一氧化氮（NO）的生物利用度被认为是通过改变生活方式（包括运动）产生肥胖效应的部分原因。4.心血管风险因素（多个风险因素）的总和显示了对每个风险因素严重程度增加的影响以及对心血管风险增加的协同效应。急性和慢性运动通过刺激核苷酸消毒机制预防氧化性DNA损伤，提示持续有氧运动可有效预防氧化性DNA损伤。