Mechanism of the prevention of the arteriosclerosis by exercise : Focused on the oxidative stress protective mechanism

本研究的目的是从氧应激及其保护机制的角度探讨有氧运动预防动脉硬化的机制。结果表明，生活方式改变对机体的氧化应激有显著影响，氧化应激防御系统、年龄、血压和BMI对氧化应激有显著影响，有氧运动可减轻氧化应激。2.干预前的氧化应激状态、尿一氧化氮水平和最大摄氧量与生活方式改变的降压效果差异有关，生活方式改变降低血压可改善其他心血管风险。3.生活方式改变后血压、体重指数、脂代谢、胰岛素抵抗和脂质过氧化均有所改善。一氧化氮(NO)的生物有效性被认为在一定程度上参与了包括运动在内的生活方式改变的降压效应。4.心血管危险因素(多个危险因素)的总和表明，每个危险因素的严重性增加的影响以及对心血管风险增加的协同作用。通过参与生活方式改变计划，提高了各危险因素的严重程度，减少了危险因素的数量。5.急性和慢性运动通过刺激核苷酸消毒机制来预防DNA氧化损伤，提示持续有氧运动对预防DNA氧化损伤是有效的。

The aim of this study was to investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.In this study, we investigate the mechanism of the effects of the aerobic exercise on arteriosclerosis prevention from the viewpoint of oxygen stress and its protective mechanism.Results were as follows ;1.As a result of lifestyle modification, it was shown that the oxidative stress to the body was significantly influenced by an oxidative stress defense system, age, blood pressure, and BMI, and aerobic exercise reduced the oxidative stress.2.The state of the oxidative stress before intervention, and urine nitric oxide level and maximum oxygen uptake were involved in the difference in the blood lowering effect by lifestyle modification, and blood pressure reduction by lifestyle modification resulted in improving other cardiovascular risks.3.Blood pressure, BMI, lipid metabolism, insulin resistance, and lipid peroxidation were shown to improve after lifestyle modification. Nitric oxide(NO) biological availability was considered to contribute, in part, to hypotensive effects by lifestyle modification including exercise..4.Summation of cardiovascular risk factors (multiple risk factor) showed the effect on the increase in the severity of each risk factor and the synergistic effect on the increase in an cardiovascular risk. Severity of each risk factor was improved and the number of risk factors were reduced by participation in lifestyle modification program.5.Acute and chronic exercise prevented oxidative DNA damage by stimulating the nucleotide sanitizing mechanism and it was suggested that continuous aerobic exercise is effective for prevention of oxidative DNA damage.