Studies on the decresed cellular inununity and dietary life in the aged

本研究研究了(1)血浆维生素E （α-生育酚）浓度，(2)血浆维生素E浓度与细胞免疫的关系，(3)维生素E对健康老年人细胞免疫的补充作用。起初，65岁以上的健康老年人血浆维生素E浓度没有下降，但高于年轻人（20-30岁）。然而，由于维生素E所含的vldl -胆固醇作为血液和老年人的状态，一般表现为血液中vhdl -胆固醇浓度较高，因此评估老年人维生素E的营养状况需要考虑血液中vldl -胆固醇浓度的变化。与年轻人相比，老年人外周血淋巴细胞的有丝分裂较低。此外，随着年龄的增长，老年人有丝分裂发生减少。血浆维生素E浓度与外周血淋巴细胞有丝分裂发生无显著相关性，而维生素E浓度/ yldl -胆固醇与外周血淋巴细胞呈显著正相关。在接下来的研究中，基于这些结果，我们研究了42名健康老年人（男性8人，女性34人）在每天摄入303 mg α-T 3个月后外周血淋巴细胞功能的变化。结果血浆α-T浓度较补充α-T前提高了1.7倍，说明本研究健康老年人对α-T的消化吸收状况良好。此外，补充α-T后，受试者血浆中vldl -胆固醇没有变化，但导致血浆中每ylpl -胆固醇α-T浓度升高。添加α-T后，外周血PHA淋巴细胞的有丝分裂率显著升高。从血浆一氧化氮（. no）浓度的变化来看，补充α-T前后无明显变化。由此可见，维持较高的维生素E血药浓度对预防肺炎等感染性疾病及其病情的恶化是有益的。本研究提示，维生素E对细胞免疫的增强不是由于一氧化氮（NO）的作用，而是由于维生素E本身的作用。少

In this study we have investigated on (1)plasma vitamin E (α-tocopherol) concentration, (2)the relationship between plasma vitamin E conentration and cellular immunity, and (3)the supplemental effect of vitamin E on celluar immunity in the healthy elderly people. At first, there was no decrease of plasma vitamin E concentration of the healthy elderly people over 65 years old, which was higher than that of young people (20-30 years old). However, since vitamin E is contained in VLDL-cholesterol as the status in the blood and the elderly people, in general, show the higher concentration of VLHL-cholesterol in blood, to assess the nutritional condition of vitamin E in the elderly people needs to consider the variation of VLDL-cholesterol concentration in blood. Mitogenesis of peripheral blood lymphocytes was lower in the elderly people compared to that of young people. In addition, the decrease of mitogenesis was seen in the elderly people with the increase of age. Although there was no s … More ignificant correlation between plasma vitamin E concentration and mitogenesis of peripheral blood lymphocytes, the positive correlation was seen between vitamin E concentration divided by YLDL-cholesterol and peripheral blood lymphocytes. In the next study based on 'these results, we have investigated the change of peripheral blood lymphocyte function in 42 healthy elderly persons (male: 8, females; 34) following the intake of 303 mg α-T per day for 3 months. As its result, plasma α-T concentration increased 1.7-fold compared to that of before the supplementation of α-T, which shows that the digestion and absorption of α-T in the healthy elderly people in this study keep good conditions. Furthermore there was no change in plasma VLDL-cholesterol of the subjects following the supplementation of α-T, which resulted in the increase of plasma α-T concentration per YLPL-cholesterol. And mitogenesis of peripheral blood lymphocytes with PHA was significantly higher after the supplementation of α-T. Considering this mechanism from the change of plasma nitric oxide (.NO) concentration, there was no significant change in before and after the supplementation of α-T. From these results, it is beneficial far elderly people to maintain higher plasma concentration of vitamin E with a view to preventing pneumonia and other infectious diseases, and the deterioration of those diseases. In this study, it is suggested that the enhanced cellular immunity by vitamin E is due to the action of not nitric oxide (NO) but vitamin E itself. Less