Synthesis of Jellyfish-Type Macrocyclic Molecular Flask and Efficient Reaction Using the Molecular Flask

水母型大环分子瓶的合成及利用该分子瓶的高效反应

基本信息

批准号：
15550039
负责人：
NISHINO Hiroshi
金额：
$ 2.43万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

This research project was proposed that an artificial molecular flask such as a cage-type mocrocyclic compound would be synthesized and a highly efficient reaction would be carried out using the molecular flask similar to that using a protein pocket in vivo. The protein pocket in vivo is a three-dimensional hole and it is an efficient reaction flask using hydrogen bond, π-electron interaction, steric repulsion, and so on. Then we planed to synthesize an original cage-type molecular macrocyclic compound using the manganese(III)-based oxidative radical macrocyclization reaction.We developed the manganese(III)-based oxidative radical macrocyclization reaction and the synthesis of up to dihydrofuran-fused fifty-membered macrocyclic compounds was achieved, This reaction is very efficient and the yield is also high. Therefore, we examined to synthesize the original cage-type molecular macrocyclic compounds using the manganese(III)-based oxidative radical macrocyclization reaction. When the c … More age-type macrocyclic compounds would be synthesized, it would be examined the following items ;1) the inclusion of a guest organic compound into the cavity of the cage-type macrocyclic compounds,2) the immobilization of the guest organic compound and reagents in the cavity using the hydrogen bond, π-electron interaction, and/or steric repulsion,3) the highly efficient reaction of the guest organic compound with reagents in the cavity,4) the extraction and separation of the products after the reaction,5) the recovery and reuse of the cage-type macrocyclic compounds.Although the cage-type macrocyclic compounds were not synthesized, sixty-five-membered cyclophene-type macrocyclic compounds were prepared. In addition, the synthesis of nine- to eighteen-membered microdiolides were achieved. Furthermore, many new guest organic molecules were synthesized.In the near future, we will plane to investigate the functional ability of the synthesized cyclophene-type macrocyclic compounds. In the event, we will achieve the synthesis of cage-type molecular macrocyclic compounds and investigate the functional ability for the biomimetic molecular flask. Finally, we will develop the highly stereoselective organic reactions using the cage-type molecular macrocyclic compounds. Less

该研究项目被提出，将合成一个人工分子瓶，例如笼型型膜型胶囊化合物，并使用类似于使用蛋白质口袋的分子瓶进行高效的反应。蛋白质口袋在体内是一个三维孔，它是使用氢键，π电子相互作用，空间排斥等有效反应瓶。然后，我们计划使用锰（III）基于氧化物（III）基于氧化物（III）基于氧化物的自由基大环化合物，使用基于二氢含量的IS二氢含量的含量与二氢含量的含量和含量相结合高的。因此，我们检查了使用基于锰（III）的氧化物自由基大环化反应的原始笼型分子大环化合物合成原始的笼子型分子大环化合物。当C综合c…更年龄型的大环化合物时，将检查以下项目； 1）将客人的有机化合物纳入笼子型大环化合物的空腔中，2）使用宾客的有机体和偶数的cavition和cavity，and cavity and cav and cav and cav and/interaction and cav and cav and cav and/interaction and interaction and cav and interaction and interactron and interactron and Interactron，cove-interaction and interactron and Interctron cove-interactron and Interactron，°π-客人有机化合物与腔中试剂的高效反应，4）反应后的产物的提取和分离，5）cage型大环化合物的恢复和再利用。尽管没有合成笼子型宏观细胞化合物，但未合成六十岁的启动的环细胞元素，以弥漫于六十分量化的环元素。此外，还达到了九至18元的微二酰亚胺的合成。此外，合成了许多新的客座有机分子。在不久的将来，我们将平面研究合成的环磷型大环化合物的功能能力。在这种情况下，我们将实现笼子型分子大环化合物的合成，并研究仿生分子瓶的功能能力。最后，我们将使用CAGE型分子大环化合物开发高度立体选择性的有机反应。较少的