Studies on the Cooperativie Transformation of Hydrogen-Bonds During the Intramolecular First-Order Transitions of Polypeptides-An Application of ^2H NMR Analysis in the Liquid Crystalline State

多肽分子内一级跃迁过程中氢键协同转变的研究——^2H NMR分析在液晶态的应用

基本信息

  • 批准号:
    15550111
  • 负责人:
  • 金额:
    $ 2.5万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2004
  • 项目状态:
    已结题

项目摘要

1.Screw-sense inversion behaviors (left- to right-handed or vice versa) of α-helical polyaspartates differ substantially depending on the chemical structure (X) of the ester group at the side-chain terminals. The cause of such phenomenological differences among polymers (X=benzyl, chlorobenzyl, and phenethyl) have been investigated by constructing the phase diagram as a function of solvent composition (TCE/TFA) and temperature.2.The helix-coil transition of polyaspartates (X=benzyl and X=phenethyl) in m-cresol at elevated temperature (a normal-type transition) has been studied by NMR methods. The observed ^1H-^1H vicinal coupling constant around the _χ1 bond rotation suggests that the g^- conformation decreases from 〜50% to 〜30% with increasing temperature in the transition region from the left-handed to random-coil state.3.The nematic conformation of main-chain liquid crystals has been studied to examine the possible incorporation of the intramolecular hydrogen-bond. The spectroscopic as well as thermodynamic (PVT) analyses led to a conclusion that a group of partially oriented conformation persists over the entire range of the nematic state. This is an encouraging evidence for the molecular design of a new class of chemical structures.
1.α-螺旋聚天冬氨酸的螺旋反转行为(从左旋到右旋或反之亦然)根据侧链末端酯基的化学结构(X)而有很大差异。通过构建作为溶剂组成 (TCE/TFA) 和温度函数的相图,研究了聚合物(X=苯甲基、氯苯甲基和苯乙基)之间这种现象学差异的原因。2.通过 NMR 研究了高温下聚天冬氨酸酯(X=苯甲基和 X=苯乙基)在间甲酚中的螺旋-螺旋转变(正型转变) 方法。观察到的^1H-^1H围绕_χ1键旋转的邻位耦合常数表明,在从左手态到无规卷曲态的过渡区域中,随着温度的升高,g^-构象从〜50%降低到〜30%。3.研究了主链液晶的向列构象,以检验分子内氢键的可能掺入。光谱和热力学(PVT)分析得出的结论是,一组部分取向的构象在向列态的整个范围内持续存在。这是一类新型化学结构的分子设计的令人鼓舞的证据。

项目成果

期刊论文数量(42)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Stepwise Phase Transition of Chain Molecules : Crystallization/Melting via a Nermatic LC Phase
链分子的逐步相变:通过向热 LC 相结晶/熔化
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A.Abe;H.Furuya;Z.Zhou;T.Hiejima;Y.Kobayashi
  • 通讯作者:
    Y.Kobayashi
Phase Behavior of Ternary Systems Involving a Conformationally Variable Chain and a Randomly Coiled Polymer
涉及构象可变链和无规卷曲聚合物的三元体系的相行为
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J.Lin;S.lin;P.Liu;T.Hiejima;H.Furuya;A.Abe
  • 通讯作者:
    A.Abe
H.Furuya, H.Iwanaga, T.Nakajima, A.Abe: "Nematic Confirmation of Oxyethylene Spacers Involved in Main-Chain Liquid Crystals"Macromol.Symp.. 192. 239-250 (2003)
H.Furuya、H.Iwanaga、T.Nakajima、A.Abe:“主链液晶中涉及的氧乙烯间隔基的向列确认”Macromol.Symp.. 192. 239-250 (2003)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Effect of the Pendant Ester Group Orientationon the Dipole Moment of Poly(alkyl acrylate)s
侧酯基取向对聚丙烯酸烷基酯偶极矩的影响
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Z.Zhou;A.Abe
  • 通讯作者:
    A.Abe
Screw-sense inversion characteristic of α-helical poly(β-p-chlorobenzyl L-aspartate) and comparison with other related polyaspartates
  • DOI:
    10.1002/bip.20207
  • 发表时间:
    2005-01-01
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Abe, A;Hiraga, K;Furuya, H
  • 通讯作者:
    Furuya, H
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ABE Akihiro其他文献

ABE Akihiro的其他文献

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{{ truncateString('ABE Akihiro', 18)}}的其他基金

Research on Information Service Design for Open-air Museum
露天博物馆信息服务设计研究
  • 批准号:
    26360070
  • 财政年份:
    2014
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analyses of cytokine responsive signaling of LPXN and enhanced responses caused by ETV6-LPXN
LPXN 的细胞因子响应信号传导和 ETV6-LPXN 引起的增强反应的分析
  • 批准号:
    25461437
  • 财政年份:
    2013
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Research on Integrated Field Museum Support System Based on Universal Design Approach
基于通用设计方法的综合野外博物馆支持系统研究
  • 批准号:
    20500230
  • 财政年份:
    2008
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Characterization of Hydrogen-bond Correlation Involved in the Helical Structure of Polypeptides and Application to the Molecular Design of Synthetic Polymers
多肽螺旋结构中氢键相关性的表征及其在合成聚合物分子设计中的应用
  • 批准号:
    18550111
  • 财政年份:
    2006
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Role of Hydrogen Bond in Polypeptides - ^2HNMR Studies in the Lyotropic Liquid Crystalline State
氢键在多肽中的作用 - 溶致液晶态的 ^2HNMR 研究
  • 批准号:
    13650959
  • 财政年份:
    2001
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular Aspects of Mesophase Formation of Polymer Liquid Crystals As Revealed by ^2H NMR Analyzes and PVT Measurements
^2H NMR 分析和 PVT 测量揭示了聚合物液晶中间相形成的分子方面
  • 批准号:
    07405045
  • 财政年份:
    1995
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
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