Interaction between cholesterol-bearing amphiphilic polyelectrolytes and surfactants

含胆固醇两亲性聚电解质与表面活性剂之间的相互作用

• 批准号: 15550112
• 负责人: MORISHIMA Yotaro
• 金额: $ 0.96万
• 依托单位: Faculty of Engineering, Fukui University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15550112/
• 关键词: Amphiphilic Polyelectrolyte; Cholesteryl group; Bile acid; Aggregation; Hydrophobic interaction; Nonionic surfactant; Micelle; Fluorescence

A hydrophobically modified polysulfonate bearing a small mole percent (5 mol %) of cholesteryl moieties forms an intermolecularly bridged flower micelle in water, arising from intermolecular associations of the polymer-bound cholesteryl groups. Binding of sodium cholate (SC) to this polymer micelle in water was investigated using ^1H NMR spin-spin relaxation time, static light scattering, quasi-elastic light scattering, and fluorescence techniques. The intermolecular association of the polymer-bound cholesteryl groups was disrupted, to some extent, by the addition of SC, resulting in the formation of complexes of the polymer-bound cholesteryl groups and SC. To investigate interactions between the polymer-bound cholesteryl groups and SC, the cholesteryl groups were labeled with a naphthalene moiety. Fluorescence spectra of the naphthalene labels and NMR spin-spin relaxation time data suggested that interactions between the aggregates of the polymer-bound cholesteryl groups and SC occurred below a critical micelle concentration of SC in water.

含有少量胆固醇的疏水改性聚磺酸盐在水中形成分子间桥接的花胶束，这是由聚合物结合的胆固醇基团的分子间结合引起的。采用^1H NMR自旋弛豫时间、静态光散射、准弹性光散射和荧光技术研究了胆酸钠（SC）与该聚合物胶束在水中的结合。在一定程度上，SC的加入破坏了聚合物结合的胆固醇基团的分子间结合，导致聚合物结合的胆固醇基团和SC形成络合物。为了研究聚合物结合的胆固醇基团和SC之间的相互作用，用萘片段标记了胆固醇基团。萘标记的荧光光谱和核磁共振自旋-自旋弛豫时间数据表明，聚合物结合的胆固醇基团聚集物与SC之间的相互作用发生在水中SC的临界胶束浓度以下。

项目成果

Fluorescence studies of associative behavior of cationic surfactant moieties covalently linked to poly(acrylamide) at the surfactant head or tail

• DOI: 10.1016/s0032-3861(02)00897-2
• 发表时间: 2003-02
• 期刊: Polymer
• 影响因子: 4.6
• 作者: H. Morimoto;A. Hashidzume;Y. Morishima

Binding of Bile Salts to an Amphiphilic Polysulfonate Modified with Cholesterol Moieties

胆汁盐与胆固醇部分修饰的两亲性聚磺酸盐的结合

• 期刊: Polymer Journal (印刷中)
• 作者: Shin-ichi Yusa

両親媒性高分子電解質の会合構造と溶液物性

两亲性聚电解质的缔合结构和溶液性质

• 期刊: オレオサイエンス (印刷中)
• 作者: Hiromi Morimoto;Akihito Hashidzume;Yotaro Morishima;遊佐 真一
• 通讯作者: 遊佐 真一

pH-Responsive Micellization of Amine-Containing Cationic Diblock Copolymers Prepared by Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization

• DOI: 10.1295/polymj.37.480
• 发表时间: 2005-07
• 期刊: Polymer Journal
• 影响因子: 2.8
• 作者: S. Yusa;Y. Konishi;Y. Mitsukami;Tohei Yamamoto;Y. Morishima

Synthesis of Well-Defined Amphiphilic Block Copolymers Having Phospholipid Polymer Sequences as a Novel Biocompatible Polymer Micelle Reagent

具有磷脂聚合物序列的明确两亲性嵌段共聚物的合成作为新型生物相容性聚合物胶束试剂

• 发表时间: 2005
• 期刊: Biomacromolecules 6
• 作者: Jonathan P.McCarney;Shin-ichi Yusa
• 通讯作者: Shin-ichi Yusa