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Control of Self-Organization of Amphiphilic Polymers by Macromolecular Architecture

大分子结构控制两亲聚合物的自组织

基本信息

批准号：
10450354
负责人：
MORISHIMA Yotaro
金额：
$ 9.09万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

We designed and synthesized amphiphilic random copolymers as follows : (1) To clarify "the character" of the hydrophobe, we synthesized amphiphilic random copolymers of sodium 2- (acrylamido) -2-methylpropanesulfonate (AMPS) and methacrylamides substituted on the N-position with saturated or unsaturated hydrocarbons by radical copolymerization with various N-substituted methacrylamides contents. (2) To investigate the effect of the spacer bonding between the hydrophobe and the polymer main chain, we synthesized amphiphilic random copolymers of AMPS with dodecyl methacrylate or with N-dodecyl-methacrylamide. Furthermore, we synthesized random copolymers of AMPS and methacrylates bearing-O (CHィイD22ィエD2CHィイD22ィエD2O)ィイD2nィエD2CィイD212ィエD2HィイD225ィエD2 with several n values.We investigated the self-organization process of these amphiphilic polymers, and characterized the structures and properties of the nano-particles formed by these polymers. (1) The properties for the hydrophobic microdomains of the nano-particles, such as microscopic dynamics, were investigated by steady-state and time-dependent fluorescence techniques using the fluorophore-labeded amphiphilic polymers. (2) The radii of gyration for the nano-particles were determined by static light scattering. The hydrodynamic sizes of the nano-particles were estimated by quasielastic light scattering, gel-permeation chromatography, and capillary electrophoresis. (3) Macroscopic dynamics of the nano-particles were investigated by quasielastic light scattering and rheometry. (4) Morphology of the nano-particles was observed by transmission electron microscopy.These results show that the self-organization of amphiphilic polymers is controlled by design of macromolecular structural factors containing the contents of hydrophobic monomers, the hydrophobes, and the spacer bondings between the hydrophobes and polymer main chain.

我们设计并合成了两亲性无规共聚物：(1)为了明确疏水性的“性质”，我们合成了2-（丙烯酰胺）-2-甲基丙磺酸钠（AMPS）和n位被饱和或不饱和烃取代的甲基丙烯酰胺，通过自由基共聚的方法合成了n -取代的甲基丙烯酰胺。(2)为了考察疏水分子与聚合物主链间间隔键的影响，我们分别与甲基丙烯酸十二酯和n -十二烷基甲基丙烯酰胺合成了AMPS两亲性无规共聚物。在此基础上，我们合成了含有o （CH′′′′D22′′D2CH′′D22′′D2O′）′′D2n′′D2C′′D212′′D2H′′D225′′D2′的AMPS和甲基丙烯酸酯无规共聚物。我们研究了这些两亲性聚合物的自组织过程，并表征了这些聚合物形成的纳米颗粒的结构和性能。(1)利用荧光团标记的两亲性聚合物，通过稳态和时间依赖荧光技术研究了纳米颗粒的疏水微域的性质，如微观动力学。(2)采用静态光散射法测定纳米颗粒的旋转半径。通过准弹性光散射、凝胶渗透色谱和毛细管电泳测定了纳米颗粒的水动力尺寸。(3)采用准弹性光散射和流变学方法研究了纳米颗粒的宏观动力学。(4)透射电镜观察纳米颗粒的形貌。这些结果表明，两亲性聚合物的自组织是由大分子结构因子的设计控制的，这些结构因子包括疏水单体的含量、疏水分子的含量以及疏水分子与聚合物主链之间的间隔键。