Control of Self-Organization of Amphiphilic Polymers by Macromolecular Architecture

大分子结构控制两亲聚合物的自组织

基本信息

批准号：
10450354
负责人：
MORISHIMA Yotaro
金额：
$ 9.09万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

We designed and synthesized amphiphilic random copolymers as follows : (1) To clarify "the character" of the hydrophobe, we synthesized amphiphilic random copolymers of sodium 2- (acrylamido) -2-methylpropanesulfonate (AMPS) and methacrylamides substituted on the N-position with saturated or unsaturated hydrocarbons by radical copolymerization with various N-substituted methacrylamides contents. (2) To investigate the effect of the spacer bonding between the hydrophobe and the polymer main chain, we synthesized amphiphilic random copolymers of AMPS with dodecyl methacrylate or with N-dodecyl-methacrylamide. Furthermore, we synthesized random copolymers of AMPS and methacrylates bearing-O (CHィイD22ィエD2CHィイD22ィエD2O)ィイD2nィエD2CィイD212ィエD2HィイD225ィエD2 with several n values.We investigated the self-organization process of these amphiphilic polymers, and characterized the structures and properties of the nano-particles formed by these polymers. (1) The properties for the hydrophobic microdomains of the nano-particles, such as microscopic dynamics, were investigated by steady-state and time-dependent fluorescence techniques using the fluorophore-labeded amphiphilic polymers. (2) The radii of gyration for the nano-particles were determined by static light scattering. The hydrodynamic sizes of the nano-particles were estimated by quasielastic light scattering, gel-permeation chromatography, and capillary electrophoresis. (3) Macroscopic dynamics of the nano-particles were investigated by quasielastic light scattering and rheometry. (4) Morphology of the nano-particles was observed by transmission electron microscopy.These results show that the self-organization of amphiphilic polymers is controlled by design of macromolecular structural factors containing the contents of hydrophobic monomers, the hydrophobes, and the spacer bondings between the hydrophobes and polymer main chain.

我们设计和合成两亲的随机共聚物如下：（1）为了澄清疏水物的“特征”，我们合成了2-（丙烯酰胺）-2-甲基丙二醇酯（Amps）（AMPS）和甲基丙烯酰胺的NOPORITARE的2-（丙烯酰胺）钠的两亲切随机共聚物，并综合了NOPIST的NOPORITARE，并取代了甲基丙烯酸酯（AMPS），并与各种N-取代的甲基丙烯酰胺含量的共聚。（2）为了研究疏水物和聚合物主链之间间隔键键的影响，我们将AMP的两亲性随机共聚物与十二烷基甲基丙烯酸酯或N-二甲基丙烯酰胺合成。此外，我们合成了AMP和甲基丙烯酸酯的随机共聚物（CHII D22CHII D22O）D2NIE D2NIE D2CII D212HII D225II D2，并具有几个N值。我们研究了这些物种的自组织，并通过这些物种的自我组织进行了这些物质的自我组织，并将其形成了这些构成的物质和这些构成的构成构成和特性的构成，这些构成了这些构成和特性的构成，并在这些物体中进行了特征，并在这些物体中进行了特征。（1）使用稳态和时间依赖性的荧光技术研究了纳米颗粒的疏水微区域的性质，例如微观动力学。（2）通过静态光散射确定纳米颗粒的回旋半径。纳米颗粒的流体动力大小是通过准灯光散射，凝胶 - 透气色谱和毛细管电泳估算的。（3）通过准灯光散射和风化测定法研究了纳米粒子的宏观动力学。（4）通过透射电子显微镜观察到纳米粒子的形态。这些结果表明，两亲聚合物的自组织由包含疏水单体，疏水物和疏水物和聚合物主链之间的含量的大分子结构因子设计。