Control of Circadian Rhythms Based on The Oscillator Model.

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In this research, we planned to propose the strategy for minimizing the adaptation failure to the shiftwork and time zone flights by controlling the entrainment mechanisms of biological rhythms. The results are summarized as follows. (1)The model of the human circadian clock mechanisms was constructed, which consists of the oscillators I, II, and SW. In addition, the photo-responsiveness was introduced to the model (2)The behavior of biological rhythms under the time-zone flights was simulated by the model The simulations showed the plausible mechanisms underlying the diverse reentrainment patterns such as the orthodrimic, antidromic, and those by partition. That is, the magnitude of photic phase response and its sign when the subject is exposed to light, and the value of the interaction function from the oscillator I to II just after the exposure to light were shown to determine the reentrainment direction. (3)Exercise during waking time in the destination could prevent the circadian … More pacemakers from its reentrainment by partition In addition to the conditions (2), the value of the interaction function from the oscillator SW to II just after the exposure to light modifies the reentrainment direction. According to these knowledge, the favorable flight schedule from Tokyo to New York was proposed to accelerate the reentrainments and reduce the expected jet lag. (4)The phase oscillator does not have the amplitude. On the other hand, the thermoregulatory model of sleep control which we previously proposed has a merit to predict the behavior of alertness under the various circumstances. However, the model application was confined to the steady state where the phase relation between the pacemakers is not expected to significantly change. In other words, it is not applicable to the environments where light-dark and sleep-waking cycles dynamically change. Here, the integrated model was constructed by combining the phase oscillator model and the thermoregulatory model of sleep control This was realized by mapping the phases of the oscillators I and II to those of the oscillators X and Y. This integrated model provides the framework for predicting the behavior of alertness and biological rhythms under the diverse light-dark cycles and working schedules. Less