Evolution and differentiation of plant pathogenic fungi mediated by horizontal gene transfer.
水平基因转移介导的植物病原真菌的进化和分化。
基本信息
- 批准号:15580033
- 负责人:
- 金额:$ 2.43万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The mechanism for determining specificity in plant-parasite interactions is one of the most intriguing issues in modern plant pathology. Although key factors that determine such specificity are unknown in most plant diseases, certain fungal pathogens are known to produce host-specific toxins(HSTs) as compatibility determinants. Our research is aimed at assessing evolution of pathogenic strategy in A.alternata pathogens that produce HSTs. We have cloned and characterized a gene (AMT) that plays a crucial role in AM-toxin biosynthesis by the apple pathotype of A.alternata and shown that it is required for pathogenicity to susceptible apple. We have also shown a polyketide synthase gene, ALT1, whose product catalyzes the production of AAL-toxin in the tomato pathotype of A.alternata. These HST biosynthetic genes reside on conditionally dispensable(CD) chromosomes found only in the pathogenic and HST-producing strains of A.alternata and homologues of the genes were not detected in nonpathogenic strains of A.alternata. This suggests that these genes may have been acquired by horizontal gene transfer and provides a possible mechanism whereby new pathotypes could arise in nature.
确定植物与寄生虫相互作用特异性的机制是现代植物病理学中最有趣的问题之一。虽然在大多数植物疾病中,决定这种特异性的关键因素尚不清楚,但已知某些真菌病原体会产生宿主特异性毒素(HSTs)作为相容性决定因素。我们的研究目的是评估产生HSTs的a.t onterata病原菌的致病策略进化。我们克隆并鉴定了一个在苹果病型葡萄霉am毒素合成中起关键作用的基因(AMT),并证明该基因对易感苹果具有致病性。我们还发现了一个聚酮合成酶基因ALT1,其产物催化了番茄a. alternata病原菌aal毒素的产生。这些HST生物合成基因存在于条件可有可无(conditional dispensable, CD)染色体上,仅存在于病菌致病菌株和产生HST菌株中,而在病菌非致病菌株中未检测到这些基因的同源物。这表明这些基因可能是通过水平基因转移获得的,并提供了一种可能的机制,即新的病理类型可能在自然界中出现。
项目成果
期刊论文数量(52)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genomic and Genetic Analysis of Plant Parasitism and Defence
植物寄生和防御的基因组和遗传分析
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Tsuge;T.
- 通讯作者:T.
The Recent Status and Perspectives of Agricultural Environment and Biotechnology
农业环境与生物技术的现状与展望
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Kodama;M.
- 通讯作者:M.
An Appropriate Increase in the Transcription of Aspergillus nidulans uvsC Improved Gene Targeting Efficiency
- DOI:10.1271/bbb.68.1649
- 发表时间:2004-01
- 期刊:
- 影响因子:0
- 作者:Toyoaki Natsume;M. Egusa;M. Kodama;Richard D. Johnson;T. Itoh;Y. Itoh
- 通讯作者:Toyoaki Natsume;M. Egusa;M. Kodama;Richard D. Johnson;T. Itoh;Y. Itoh
Host-specific toxins produced by plant-pathogenic fungi : Molecular mechanisms of binsynthesis and host recognition.
植物病原真菌产生的宿主特异性毒素:合成和宿主识别的分子机制。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Otani;H.
- 通讯作者:H.
Detection of fungi producing infection-inhibiting metabolites against Alternaria alternata Japanese pear pathotype from fungi inhabiting internal tissues of Japanese pear shoots
从栖息在日本梨枝条内部组织的真菌中检测产生针对链格孢日本梨病型的感染抑制代谢物的真菌
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Arem;E.A
- 通讯作者:E.A
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KODAMA Motoichiro其他文献
KODAMA Motoichiro的其他文献
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{{ truncateString('KODAMA Motoichiro', 18)}}的其他基金
Molecular mechanisms of pathogenicity of phytopathogenic and entomopathogenic fungi based on a common toxin production
基于共同毒素产生的植物病原和昆虫病原真菌致病性的分子机制
- 批准号:
23658041 - 财政年份:2011
- 资助金额:
$ 2.43万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Toxin and elicitor: a comparative analysis of functions and pathological roles of cell death inducers from plant pathogenic fungi
毒素和激发子:植物病原真菌细胞死亡诱导剂的功能和病理作用的比较分析
- 批准号:
23380025 - 财政年份:2011
- 资助金额:
$ 2.43万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Toxin vs. elicitor : a comparative analysis of function and evolution of cell death inducers from plant pathogenic fungi
毒素与诱导子:植物病原真菌细胞死亡诱导剂的功能和进化的比较分析
- 批准号:
20380028 - 财政年份:2008
- 资助金额:
$ 2.43万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Evolution and differentiation of plant pathogenic fungi mediated by pathogenicity chromosomes
致病性染色体介导的植物病原真菌的进化与分化
- 批准号:
18580041 - 财政年份:2006
- 资助金额:
$ 2.43万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mechanisms of host-recognition by plant pathogens mediated by signaling factors for pathogenicity
致病性信号因子介导的植物病原体宿主识别机制
- 批准号:
13660052 - 财政年份:2001
- 资助金额:
$ 2.43万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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06660053 - 财政年份:1994
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- 批准号:
02044099 - 财政年份:1990
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