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Development of the electricity stimulation drugs discharge chip, and its practical application to the discharge control that combined lbiosensor

电刺激药物放电芯片的研制及其在结合生物传感器放电控制中的实际应用

基本信息

批准号：
15590035
负责人：
KASHIWAGI Yoshitomo
金额：
$ 2.37万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

This research did the research regarding the discharge control that combined the development and biosensor of the electricity stimulation drugs discharge chip. It was able to produce it by fixating the cation nature drugs on the foundation by utilizing the interaction of static electricity by surface castings after the element that can discharge the drugs by a direct reaction with the electrode covered Nafion on the foundation electrode. On the other hand, an indirect electricity reaction style element does production the pyrrole derivative that replaced the bipyridinium salt that turns on the discharge drugs pair ion and able to produce by fixating upward a foundation by an electrochemical polymerization reaction. By controlling the controlled potential electrolysis, even in either element that was produced these the discharge quantity of the drugs that is fixed able to be controlled release. On the other hand, the discharge quantity of the drugs that is fixed able to be controlled re … More lease, by controlling a/the setting potential in the controlled current electrolysis. Furthermore, by making a/the setting current minimum it came the discharge start of the drugs that is fixed with a delay.Next, I did the research regarding the unification between the electricity stimulation drugs discharge chip and biosensor. The insulin was discharged from the drugs discharge element when it reached the treatment area, as I tried the discharge control of the insulin that is diabetes treatment medicine while giving monitoring to the target when it combines, passes the drugs discharge element and glucose sensor first of all. Also, make the storeroom the pyramid state such that the drugs delivery utilize the technology of microinjection etc.to the foundation by using, silicon aiming at, the development of a possible element with the long time cycle and able to fill up little quantity precisely and cover the surface in the gold membrane where can prevent the corrosion by oxygen and chlorine ion etc.and overturned with silicon dioxy film to also prevent corrosion even positive pole and, the negative pole. The drugs fixate the functionability material that discharging by electricity stimulation on the positive pole of this element, the corrosiveness inside the living body was investigated. This electricity stimulation drugs discharge chip see the wisdom which the drugs delivery are possible with the long time cycle, without being corroded without receiving the influence at all during the solution of the component similar to living body inside as a result, and obtained. Less

本研究将电刺激药物放电芯片的开发与生物传感器相结合进行放电控制方面的研究。它是通过表面铸件与基础电极上覆盖的Nafion电极直接反应而释放药物的元件后，利用静电相互作用，将阳离子性质的药物固定在基础上来生产的。另一方面，间接电反应式元件确实产生取代联吡啶鎓盐的吡咯衍生物，联吡啶盐开启放电药物对离子，并且能够通过电化学聚合反应固定在基础上来产生。通过控制受控电位电解，即使在所产生的任一元件中，也能够控制释放固定的药物的排出量。另一方面，通过控制受控电流电解中的设定电位，可以控制释放固定的药物的排放量。此外，通过将设定电流设为最小，可以延迟固定药物的释放开始。接下来，我进行了关于电刺激药物释放芯片和生物传感器之间的统一的研究。当胰岛素到达治疗区域时，胰岛素从药物排出元件排出，因为我尝试了糖尿病治疗药物胰岛素的排出控制，同时在其结合时首先通过药物排出元件和葡萄糖传感器对目标进行监测。另外，将库房做成金字塔状，以便药物输送利用显微注射等技术，以硅为基础，开发出一种周期长、能够精确填充少量的可能元素，并在金膜表面覆盖可以防止氧和氯离子等腐蚀的金膜，并用二氧化硅膜翻转，甚至可以防止正极腐蚀，负极。该药物将通过电刺激放电的功能性材料固定在该元件的正极上，研究其在生物体内的腐蚀性。结果，获得了这种电刺激药物释放芯片，其结果是，在类似于生物体内部的成分的溶解过程中，完全不会受到腐蚀，而不会受到任何影响，可以以长的时间周期进行药物释放。较少的