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Assessment of Peripheral Circulatory Function among Workers Exposed to Hand-Arm Vibration using Laser Doppler Perfusion Imager

使用激光多普勒灌注成像仪评估手臂振动工人的周围循环功能

基本信息

批准号：
15590511
负责人：
TOMIDA Kotaro
金额：
$ 2.24万
依托单位：
Wakayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Laser Doppler perfusion imaging(LDPI) is a new technique for mapping cutaneous blood flow. The method employs a two-dimensional horizontal scanning of the flow in a specific tissue, and makes it possible to visualize the spatial variation over the region of interest. The aim of this study was to clarify the usefulness of the LDPI technique in the assessment of peripheral circulatory functions among workers exposed to hand-arm vibration.In the preliminary study, we measured the finger skin blood perfusion of 8 young healthy male volunteers (34.1±2.9 years) using LDPI in various testing conditions. The skin blood perfusion decreased markedly under the room temperature of 21℃ compared to 23℃ and 25℃ conditions. Significant differences in the perfusion values were observed between the three levels of room temperature. In addition, the finger skin blood perfusion tended to be low during the hand was immersed in water, irrespective of the water temperature. However, the decrease of perfusion … More during the immersion was slight and showed similar values independent of the depths under the water. It is, therefore, suggested that the LDPI technique enables a monitoring of skin blood perfusion of the hand being immersed in cold water and that the assessment of skin blood perfusion requires a strictly controlled condition of ambient temperature.In the experimental study, the changes in the finger skin blood perfusion in response to cold water immersion test (10℃, 10min) were evaluated in 47 male volunteers aged 27 to 63 years (42.5±8.4 years). None of the subjects had complications relating to peripheral circulatory impairments of the hands. The finger blood perfusion reduced sharply as a result of immersion of the hand in cold water. However, the perfusion value increased gradually until the end of the immersion. After removal of the hand from the cold water, the finger blood perfusion recovered rapidly and nearly reached the baseline value. The blood perfusion values were significantly correlated with age, and subjects in the 50 years group had significantly lower values than the 30 years group. These results indicate that the changes in finger skin blood perfusion in response to cold water immersion are different by age group and thus the age-related variation should be considered in the assessment of peripheral circulatory function of workers exposed to hand-arm vibration.In addition, we examined 16 subjects, aged 46 to 59 years (52.9±3.4 years), who were selected from workers operating vibrating tools such as chainsaws and bush cleaners in private forestry enterprises. When compared to the control subjects of similar age, the vibration-exposed subjects had lower finger skin blood perfusion at baseline. The blood perfusion of the exposed subjects remained unchanged at the lowest level over the period of cold water immersion, while that of the control subjects showed a gradual increase. At the recovery phase following the immersion, the blood perfusion of exposed subjects had no tendency to recover as the time span increased. There were significant differences in the perfusion values of the two groups of subjects at baseline, the latter phase of the cold water immersion, and throughout the recovery period after statistical adjustments for the effects of age and room temperature.In conclusion, the findings of this study suggest that the LDPI technique enables visualizing and quantifying the peripheral vascular effects of cold water immersion on the finger skin blood perfusion and thus has the potential of providing more detailed and accurate information that may help detect the peripheral circulatory impairment in the fingers of vibration-exposed workers. Less

激光多普勒血流成像(LDPI)是一种新的皮肤血流成像技术。该方法对特定组织中的流动进行二维水平扫描，并使其能够可视化感兴趣区域的空间变化。为探讨LDPI技术在评估手臂振动作业工人外周循环功能中的应用价值，在初步研究中，我们使用LDPI技术对8名年轻健康男性志愿者(34.1±2.9岁)在不同测试条件下的手指皮肤血液灌注量进行了测量。与23℃和25℃相比，21℃室温下皮肤血液灌注量显著降低。在三种不同的室温水平下，灌注值有显著差异。此外，在手浸入水中时，手指皮肤的血液灌注量往往较低，与水温无关。然而，…灌注量的降低在浸泡过程中更多的是轻微的，并显示出类似的值，独立于水下的深度。在实验研究中，我们观察了47名男性志愿者在冷水浸泡试验(10℃，10min)后手指皮肤血液灌注量的变化。所有受试者均未出现与手部外周循环障碍相关的并发症。由于将手浸入冷水中，手指的血液灌注量急剧下降。然而，灌注值逐渐增加，直到浸泡结束。将手从冷水中取出后，手指血液灌注量迅速恢复，接近基线水平。血流灌注值与年龄显著相关，50岁组受试者明显低于30岁组受试者。这些结果表明，冷水浸泡时手指皮肤血液灌注量的变化因年龄而异，因此在评估手臂振动作业工人的外周循环功能时应考虑年龄相关性变化。此外，我们从私营林业企业使用链锯和灌木清洗机等振动工具的工人中挑选了16名年龄在46~59岁(52.9±3.4岁)的被试。与年龄相近的对照组相比，接触振动的受试者在基线时手指皮肤的血液灌注量较低。暴露组的血液灌注量在冷水浸泡期间保持在最低水平不变，而对照组的血液灌注量则呈逐渐增加的趋势。在浸泡后的恢复期，暴露受试者的血液灌注量没有随着时间的延长而恢复的趋势。两组受试者在冷水浸泡前、冷水浸泡后期和整个恢复期的灌注值在对年龄和室温的影响进行统计调整后均有显著差异。综上所述，本研究的结果表明，LDPI技术可以可视化和量化冷水浸泡对手指皮肤血液灌注量的外周血管影响，从而有可能提供更详细和准确的信息，有助于检测振动暴露工人手指的外周循环损害。较少