Investigation of physicochemical property of respirable dust for predicators of lung injury

肺损伤预测因素可吸入粉尘的理化性质研究

• 批准号: 15590528
• 负责人: OYABU Takako
• 金额: $ 2.05万
• 依托单位: University of Occupational and Environmental Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590528/
• 关键词: Respirable particles; Bioperisitence; Solubility; Particle shape; Intratracheal instillation; Fibrosis; 幾何形状

The adverse health effects of respirable particles in the working environment are thought to depend on the biopersistence of the inhaled particles in the lung. The solubility of the particle in the lung and particle shape are two main physicochemical factors which have an influence on the biopersistence. In this study, three different types of respirable particles were selected and the effect of "solubility" and "shape" of the particles on their biopersistence was investigated.We first measured the solubilities of three types of particles accurately by using a solubility measurement apparatus which we devised. We also measured the geometric mean diameter and length for fibrous particles and the geometric mean diameter for non-fibrous particles.Comparing the results of the physicochemical properties with the biopersistence of the particles in vivo, we concluded as follows :1.The results of a comparison between potassium octatitanate whisker and magnesium sulfate whisker, whose shapes are almost identical, showed that biopersistence was longer for the low solubility than for that of the high solubility.2.Similarly, the comparison results for potassium octatitanate particle and potassium octatitanate whisker, whose solubility is almost identical, showed that biopersistence was longer for the fibrous particle than that of the non-fibrous particle.3.It is suggested that the solubility and the shape of respirable particles will be a useful indicator for lung injury.

工作环境中可吸入颗粒物对健康的不利影响被认为取决于吸入颗粒物在肺部的生物持久性。颗粒在肺中的溶解度和颗粒形状是影响其生物持久性的两个主要物理化学因素。本研究选取了三种不同类型的可吸入颗粒物，研究了颗粒物的“溶解度”和“形状”对其生物持久性的影响，首先利用自行设计的溶解度测量装置准确地测量了三种颗粒物的溶解度。我们还测量了纤维状颗粒的几何平均直径和长度以及非纤维状颗粒的几何平均直径。将理化性质的结果与体内颗粒的生物持久性进行了比较，得出以下结论：1.形状几乎相同的辛酸钾晶须和硫酸镁晶须的比较结果表明，低溶解度的晶须的生物持久性比高溶解度的要长。2.同样，溶解度几乎相同的辛酸钾颗粒和辛酸钾晶须的比较结果也是如此。说明可吸入颗粒物的生物持久性比非纤维性颗粒物更长。3.可吸入颗粒物的溶解度和形状可作为肺损伤的有用指标。