Investigation for establishment of the indicators of alcohol intake by mean corpuscular volume, γ-GTP, and the inquiry method

（目的）在日本健康21中，推荐的酒精摄入量小于或等于1 gou清酒（=乙醇22 g）。据报道，少量饮酒可减少脑梗死，尽管γ-谷氨酰转肽酶（γ-GTP）被认为是酒精指标，但它并不与酒精摄入平行，尤其是在女性中。此外，平均红细胞体积（MCV）并没有被广泛用作酒精摄入量的指标。本文的目的是确定MCV和γ-GTP在适量饮酒人群中的临界值。而我们则转向教导没有并发症和疾病的人适当的饮酒方法成为目的。（方法）（1）对6989名30 ~ 69岁健康体检者进行健康体检，比较不同酒精浓度组MCV和γ-GTP的变化。（2）用受试者工作特征曲线计算相应于适当乙醇（男性150 g，女性100 g）的MCV和γ-GTP的临界值。乙醇是每周的酒精摄入量，以克乙醇表示。(3)We检查了MCV与维生素B_和叶酸的关系<12>。（结果）（1）MCV随乙醇浓度的增加而升高;男性中γ-GTP的增加与乙醇平行，但女性中没有。（2）MCV和γ-GTP的临界值，男性分别为92 fL/L和40 IU/L，女性分别为90 fL/L和17 IU/L。（3）MCV与维生素B_2、叶酸均无相关性<12>。（结论）（1）MCV可作为男性和女性饮酒量的指标，而γ-GTP仅可作为男性饮酒量的指标。（2）总体而言，MCV和γ-GTP的临界值对饮酒课是有效的。

(Objective)In Health Japan 21, the recommended alcohol intake is less than or equal to 1 gou of sake(=ethanol 22g). It is reported a little drinking reduces cerebral infarction.Although Gamma-glutamyl transpeptidase (γ-GTP) is known as an alcohol indicator, it does not parallel alcohol intake, especially in women. In addition, mean corpuscular volume(MCV) is not widely used as an indicator of alcohol intake. The purpose of this article is to determine the cut-off value of MCV and γ-GTP in the population consuming appropriate amount of alcohol. And we turned to teach the appropriate drinking method to the person without complication and disease into a purpose.(Methods)(1)Total of 6989 subjects aged 30 to 69 years were recruited during our health check-up, and MCV and γ-GTP were compared between different Ethanol groups. (2)The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol(150 g in men, and 100 g in women) were calculated using receiver operating characteristic curves. Ethanol is alcohol intake per week expressed in gram of ethanol. (3)We examined relation of MCV and both Vitamin B_<12> and folic acid. (Results)(1)MCV elevated with the increase of Ethanol in both sex. γ-GTP in men increased parallel to Ethanol, but not in women. (2)The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol were 92 fL/L and 40IU/L in men, and 90fL/L and 17 IU/L in women, respectively. (3)MCV was not related with both Vitamin B_<12> and folic acid. (Conclusion)(1)MCV is an indicator of alcohol intake in both sex, while γ-GTP is an indicator only in men. (2)Overall, the cut-off values for MCV and γ-GTP is effective for a drinking lesson.