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Investigation for establishment of the indicators of alcohol intake by mean corpuscular volume, γ-GTP, and the inquiry method

平均红细胞体积、γ-GTP饮酒指标的建立及探究方法的探讨

基本信息

批准号：
15590559
负责人：
FUKUMOTO Tsutomu
金额：
$ 0.77万
依托单位：
Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590559/
关键词：
maen corpuscular volume Vitamin B_<12>folic acid appropriate drinking γ-GTP ビタミンB_<12>

项目摘要

(Objective)In Health Japan 21, the recommended alcohol intake is less than or equal to 1 gou of sake(=ethanol 22g). It is reported a little drinking reduces cerebral infarction.Although Gamma-glutamyl transpeptidase (γ-GTP) is known as an alcohol indicator, it does not parallel alcohol intake, especially in women. In addition, mean corpuscular volume(MCV) is not widely used as an indicator of alcohol intake. The purpose of this article is to determine the cut-off value of MCV and γ-GTP in the population consuming appropriate amount of alcohol. And we turned to teach the appropriate drinking method to the person without complication and disease into a purpose.(Methods)(1)Total of 6989 subjects aged 30 to 69 years were recruited during our health check-up, and MCV and γ-GTP were compared between different Ethanol groups. (2)The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol(150 g in men, and 100 g in women) were calculated using receiver operating characteristic curves. Ethanol is alcohol intake per week expressed in gram of ethanol. (3)We examined relation of MCV and both Vitamin B_<12> and folic acid. (Results)(1)MCV elevated with the increase of Ethanol in both sex. γ-GTP in men increased parallel to Ethanol, but not in women. (2)The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol were 92 fL/L and 40IU/L in men, and 90fL/L and 17 IU/L in women, respectively. (3)MCV was not related with both Vitamin B_<12> and folic acid. (Conclusion)(1)MCV is an indicator of alcohol intake in both sex, while γ-GTP is an indicator only in men. (2)Overall, the cut-off values for MCV and γ-GTP is effective for a drinking lesson.

（目标）健康日本21中，建议的酒精摄入量小于或等于1戈清酒（=乙醇22克）。据报道，少量饮酒可减少脑梗塞。虽然γ-谷氨酰转肽酶（γ-GTP）被称为酒精指标，但它并不与酒精摄入量平行，尤其是女性。此外，平均红细胞体积（MCV）并未广泛用作酒精摄入量的指标。本文的目的是确定适量饮酒人群中 MCV 和 γ-GTP 的临界值。并转而向无并发症、无疾病的人传授适当的饮用方法为目的。(方法)(1)健康检查共纳入6989名30～69岁受试者,比较不同乙醇组之间的MCV和γ-GTP。 (2)利用受试者工作特征曲线计算相应乙醇(男性150g、女性100g)对应的MCV和γ-GTP截止值。乙醇是每周的酒精摄入量，以乙醇克数表示。 (3)研究了MCV与维生素B_ 12 和叶酸两者的关系。 (结果)(1)男女MCV均随乙醇浓度的增加而升高。男性中的 γ-GTP 与乙醇平行增加，但女性中则不然。 (2)适当乙醇对应的MCV和γ-GTP截止值男性分别为92fL/L和40IU/L，女性为90fL/L和17IU/L。 (3)MCV与维生素B_12和叶酸均无关。 (结论)(1)MCV是男女酒精摄入量的指标，而γ-GTP仅是男性的指标。 (2)总体而言，MCV 和 γ-GTP 的截止值对于饮酒课程是有效的。