权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Quantitative evolution of family history of coronary heart disease considering their sex and age

考虑性别和年龄的冠心病家族史的定量演变

基本信息

批准号：
15590569
负责人：
SAITO Tomohiro
金额：
$ 1.34万
依托单位：
National Research Institute for Child Health and Development
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590569/
关键词：
family history coronary disease age sex risk factor リスク因子性別遺伝誤分類バイアス

项目摘要

The influence of sex and age on the positivity of family history were assessed numerically.Through questionnaires filled in by the parents of 2316 high school students, information was obtained on the past history of coronary heart disease among students' parents, grandparents, uncles and aunts. The sex- and age-specific proportion of a positive history was calculated from the past history among the 24,071 family members. The influence of sex and age on a positive history were estimated as odds ratios by logistic regression analysis of the past history.The odds ratios obtained for sex and age difference were 1.61 (95% confidence interval : 1.42-1.83) and 1.07 (95% confidence interval : 1.06-1.07), respectively. This indicated that a positive history was 1.61 times higher in male members than in female members of the same age and that a positive history increased by (1.07) y, where y was age difference by one year.Precision of the family history obtained through questionnaires was examined.A questionnaire survey of 438 high school students on the family history of lifestyle-related diseases among the students' parents, grandparents, uncles and aunts was conducted twice with a one-year interval. The questionnaire was filled in by their parents. Discordance between the two questionnaires in age, age at death and a positive history of lifestyle-related diseases expressed by age at onset by decade age among the family members was calculated as the index for precision.The discordance tended to be higher among grandparents than parents, uncles and aunts. The discordance was mostly below a few percent in angina pectoris, myocardial infarction, stroke and diabetes mellitus. It was a little higher in hypertension and hypercholesterolemia but remained below several percent.

对性别和年龄对家族史阳性的影响进行数值评估。通过对2316名高中生家长填写的调查问卷，获取了学生父母、祖父母、叔叔阿姨的既往冠心病史信息。根据 24,071 名家庭成员的既往病史计算出阳性病史的性别和年龄特定比例。通过对既往病史进行逻辑回归分析，将性别和年龄对阳性病史的影响估计为比值比。性别和年龄差异的比值比分别为 1.61（95% 置信区间：1.42-1.83）和 1.07（95% 置信区间：1.06-1.07）。这表明，男性成员的阳性史是同龄女性的1.61倍，阳性史增加了(1.07)y，其中y为年龄差1岁。检验了通过问卷调查获得的家族史的准确性。对438名高中生的父母、祖父母、叔叔阿姨进行了两次为期一年的生活方式相关疾病家族史问卷调查。间隔。调查问卷由家长填写。计算两份问卷在家庭成员中年龄、死亡年龄以及以发病年龄到十岁之间表示的生活习惯病阳性史之间的不一致程度作为精确度指标。祖父母之间的不一致程度往往高于父母、叔叔阿姨。心绞痛、心肌梗塞、中风和糖尿病的不一致程度大多低于几个百分点。高血压和高胆固醇血症的比例略高，但仍低于几个百分点。