Quantitative evolution of family history of coronary heart disease considering their sex and age

通过对2316名高中生家长进行问卷调查，了解其父母、祖父母、叔叔、阿姨的冠心病既往病史。根据24,071名家庭成员的既往病史计算出阳性病史的性别和年龄比例。通过对既往病史的Logistic回归分析，估计了性别和年龄对阳性病史的影响，得到性别和年龄差异的优势比分别为1.61(95%可信区间：1.42~1.83)和1.07(95%可信区间：1.06~1.07)。通过问卷调查，对438名高中生父母、祖父母、叔叔、阿姨的生活方式相关疾病家族史进行了两次问卷调查。问卷是由他们的父母填写的。两份问卷在年龄、死亡年龄以及家庭成员中以十岁为单位表示的生活方式相关疾病阳性史之间的不一致性被计算为精确度指数。祖父母之间的不一致性往往高于父母、叔叔和阿姨。心绞痛、心肌梗死、中风和糖尿病的不符合率大多低于几个百分点。在高血压和高胆固醇血症中，这一比例略高，但仍低于几个百分点。

The influence of sex and age on the positivity of family history were assessed numerically.Through questionnaires filled in by the parents of 2316 high school students, information was obtained on the past history of coronary heart disease among students' parents, grandparents, uncles and aunts. The sex- and age-specific proportion of a positive history was calculated from the past history among the 24,071 family members. The influence of sex and age on a positive history were estimated as odds ratios by logistic regression analysis of the past history.The odds ratios obtained for sex and age difference were 1.61 (95% confidence interval : 1.42-1.83) and 1.07 (95% confidence interval : 1.06-1.07), respectively. This indicated that a positive history was 1.61 times higher in male members than in female members of the same age and that a positive history increased by (1.07) y, where y was age difference by one year.Precision of the family history obtained through questionnaires was examined.A questionnaire survey of 438 high school students on the family history of lifestyle-related diseases among the students' parents, grandparents, uncles and aunts was conducted twice with a one-year interval. The questionnaire was filled in by their parents. Discordance between the two questionnaires in age, age at death and a positive history of lifestyle-related diseases expressed by age at onset by decade age among the family members was calculated as the index for precision.The discordance tended to be higher among grandparents than parents, uncles and aunts. The discordance was mostly below a few percent in angina pectoris, myocardial infarction, stroke and diabetes mellitus. It was a little higher in hypertension and hypercholesterolemia but remained below several percent.