Quantitative evolution of family history of coronary heart disease considering their sex and age

通过对2316名高中生家长的问卷调查，了解父母、祖父母、叔叔、阿姨的冠心病既往史，并对性别、年龄对冠心病家族史阳性率的影响进行数值分析。根据24，071名家庭成员的既往病史计算了特定性别和年龄的阳性病史比例。对既往病史进行Logistic回归分析，得出性别和年龄对阳性史的影响的比值比分别为1.61（95%可信区间：1.42-1.83）和1.07（95%可信区间：1.06-1.07）。这表明，男性成员的阳性病史是同龄女性成员的1.61倍，对438名高中生的父母进行生活方式相关疾病家族史问卷调查，对祖父母、叔叔和阿姨进行了两次调查，每次间隔一年。问卷由家长填写。两份问卷在年龄、死亡年龄和家庭成员中以发病年龄和10岁年龄表示的生活方式相关疾病阳性史方面的不一致性被计算为精确度指数，祖父母之间的不一致性往往高于父母、叔叔和阿姨。心绞痛、心肌梗死、脑卒中、糖尿病的不一致性大多在百分之几以下。在高血压和高胆固醇血症中略高，但仍低于百分之几。

The influence of sex and age on the positivity of family history were assessed numerically.Through questionnaires filled in by the parents of 2316 high school students, information was obtained on the past history of coronary heart disease among students' parents, grandparents, uncles and aunts. The sex- and age-specific proportion of a positive history was calculated from the past history among the 24,071 family members. The influence of sex and age on a positive history were estimated as odds ratios by logistic regression analysis of the past history.The odds ratios obtained for sex and age difference were 1.61 (95% confidence interval : 1.42-1.83) and 1.07 (95% confidence interval : 1.06-1.07), respectively. This indicated that a positive history was 1.61 times higher in male members than in female members of the same age and that a positive history increased by (1.07) y, where y was age difference by one year.Precision of the family history obtained through questionnaires was examined.A questionnaire survey of 438 high school students on the family history of lifestyle-related diseases among the students' parents, grandparents, uncles and aunts was conducted twice with a one-year interval. The questionnaire was filled in by their parents. Discordance between the two questionnaires in age, age at death and a positive history of lifestyle-related diseases expressed by age at onset by decade age among the family members was calculated as the index for precision.The discordance tended to be higher among grandparents than parents, uncles and aunts. The discordance was mostly below a few percent in angina pectoris, myocardial infarction, stroke and diabetes mellitus. It was a little higher in hypertension and hypercholesterolemia but remained below several percent.