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A trial for reducing false-positives in screening for neuroblastoma by baby food developed for the screening

一项通过为筛查开发的婴儿食品减少神经母细胞瘤筛查假阳性的试验

基本信息

批准号：
60870025
负责人：
SAITO Tomohiro
金额：
$ 0.83万
依托单位：
School of Nursing and Medical Technology, University of Occupational and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60870025/
关键词：
Neuroblastoma スクリーニング偽陽性

项目摘要

An experimental and an epidemiologic studies were conducted with the aims of firstly clarifying the cause of false-positives in screening for neuroblastoma by measurement of urine VMA collected with filter paper, secondly reducing falsepositives by developing baby food for the screening, and thirdly establishing new guidance to mothers of 6-month-old babies, candidates for the screening.The research consisted of three phases. Firstly, investigation of the doseeffect and time relationsip in vivo between the urine test and intake of contraindicated food, known to cause false-positives in vitro, when taken by babies and when taken by mothers who breast feed. Secondly, a population trial to reduce false-positives by advising mothers to give baby food developed for the screening. Thirdly, investigation through a questionnair survey of the difference between negative and false-positive babies in foodstuffs taken before the screening.The result of the experimental study revealed the following. Orange juice and banana taken orally by infants induced a very high false-positive rate. The falsepositive results lasted from one to several hours after intake and after 20 hours no positive result was found. No apparent dose-effect relationship was observed for the intake of orange juice. Substances in orange juice causing false-positives passed to infants through breast milk and this lasted for more than 20 hours.The population trial yielded the following results. No difference was observed in the false-positive rate between those infants under the guidance and those without the guidance. Proportion of infants who took other food than was indicated was 37% in the negative group and 47% in the false-positive group, but the difference was not statistically significant. Further analysis of the difference in the types of food taken between the two groups is needed.

进行了一项实验和流行病学研究，目的首先是通过测量滤纸收集的尿液 VMA 来澄清神经母细胞瘤筛查中假阳性的原因，其次通过开发用于筛查的婴儿食品来减少假阳性，第三为筛查候选者 6 个月大婴儿的母亲建立新的指导。该研究分为三个阶段。首先，研究尿检与禁忌食物摄入之间的体内剂量效应和时间关系，已知在婴儿服用和母乳喂养的母亲服用时，禁忌食物会导致体外假阳性。其次，进行了一项人口试验，通过建议母亲为筛查开发婴儿食品来减少假阳性。第三，通过问卷调查的方式，对筛查前所吃的食物中阴性和假阳性婴儿的差异进行调查。实验研究的结果揭示了以下内容。婴儿口服橙汁和香蕉引起的假阳性率非常高。假阳性结果在摄入后持续一到几个小时，20小时后没有发现阳性结果。对于橙汁的摄入没有观察到明显的剂量效应关系。橙汁中引起假阳性的物质通过母乳传递给婴儿，这种情况持续了20多个小时。人群试验得出了以下结果。接受指导的婴儿与未接受指导的婴儿之间的假阳性率没有差异。阴性组中食用其他食物的婴儿比例为 37%，假阳性组中为 47%，但差异无统计学意义。需要进一步分析两组之间摄入食物类型的差异。