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A trial for reducing false-positives in screening for neuroblastoma by baby food developed for the screening

一项通过为筛查开发的婴儿食品减少神经母细胞瘤筛查假阳性的试验

基本信息

批准号：
60870025
负责人：
SAITO Tomohiro
金额：
$ 0.83万
依托单位：
School of Nursing and Medical Technology, University of Occupational and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60870025/
关键词：
Neuroblastoma スクリーニング偽陽性

项目摘要

An experimental and an epidemiologic studies were conducted with the aims of firstly clarifying the cause of false-positives in screening for neuroblastoma by measurement of urine VMA collected with filter paper, secondly reducing falsepositives by developing baby food for the screening, and thirdly establishing new guidance to mothers of 6-month-old babies, candidates for the screening.The research consisted of three phases. Firstly, investigation of the doseeffect and time relationsip in vivo between the urine test and intake of contraindicated food, known to cause false-positives in vitro, when taken by babies and when taken by mothers who breast feed. Secondly, a population trial to reduce false-positives by advising mothers to give baby food developed for the screening. Thirdly, investigation through a questionnair survey of the difference between negative and false-positive babies in foodstuffs taken before the screening.The result of the experimental study revealed the following. Orange juice and banana taken orally by infants induced a very high false-positive rate. The falsepositive results lasted from one to several hours after intake and after 20 hours no positive result was found. No apparent dose-effect relationship was observed for the intake of orange juice. Substances in orange juice causing false-positives passed to infants through breast milk and this lasted for more than 20 hours.The population trial yielded the following results. No difference was observed in the false-positive rate between those infants under the guidance and those without the guidance. Proportion of infants who took other food than was indicated was 37% in the negative group and 47% in the false-positive group, but the difference was not statistically significant. Further analysis of the difference in the types of food taken between the two groups is needed.

本文通过实验研究和流行病学研究，首先阐明利用滤纸采集尿液VMA进行神经母细胞瘤筛查假阳性的原因，其次通过开发用于筛查的婴儿食品来减少假阳性，第三为筛查候选6个月婴儿的母亲提供新的指导。研究分为三个阶段。首先，调查婴儿和母乳喂养的母亲在体内服用禁忌症食物时尿液测试与摄入禁忌症食物之间的剂量效应和时间关系，这些食物在体外会导致假阳性。其次，通过建议母亲为筛查提供婴儿食品来减少假阳性结果的人口试验。第三，通过问卷调查，对筛查前所取食品中阴性和假阳性婴儿的差异进行调查。实验研究的结果揭示了以下几点。婴儿口服橙汁和香蕉会导致很高的假阳性率。假阳性结果持续1 ~数小时，20小时后无阳性结果。橙汁的摄入没有明显的剂量效应关系。橙汁中导致假阳性的物质通过母乳传给婴儿，这种情况持续了20多个小时。人口试验得出了以下结果。指导组与未指导组的假阳性率差异无统计学意义。阴性组和假阳性组婴儿服用非指示食物的比例分别为37%和47%，但差异无统计学意义。需要进一步分析这两组人所吃食物种类的差异。