The roles of intestinal micro flora and it's metabolites, bile acids, and sulfated polysaccharides in the inflammatory bowel disease.

肠道菌群及其代谢物、胆汁酸和硫酸多糖在炎症性肠病中的作用。

• 批准号: 15590640
• 负责人: ARAKI Yoshio
• 金额: $ 2.3万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590640/
• 关键词: bile acid; permeability; protein kinase C; sulfated polysaccharide; 炎症性腸疾患; Clostridium butyricum

In the present study, we have made it clear that1.bile acids increase the permeability of intestinal epithelium via the generation of reactive oxygen species, and the activation of intracellular signaling systems such as protein kinase C,2.sulfated polysaccharides such as dextran sulfate sodium can be depolymerized in the gut lumen.

在目前的研究中，我们已经表明，1。胆汁酸通过产生活性氧和激活细胞内信号系统（如蛋白激酶C，2）来增加肠上皮的通透性。硫酸酸化的多糖，如硫酸葡聚糖钠，可在肠腔内解聚。

项目成果

The long-term oral administration of a product derived from a probiotic, Clostridium butyricum induced no pathological effects in rats.

• DOI: 10.3892/ijmm.12.4.571
• 发表时间: 2002-02
• 期刊: International journal of molecular medicine
• 影响因子: 5.4
• 作者: Y. Araki;A. Andoh;J. Takizawa;W. Takizawa;Y. Fujiyama

Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats.

• DOI: 10.3892/ijmm.13.4.577
• 发表时间: 2004-04
• 期刊: International journal of molecular medicine
• 影响因子: 5.4
• 作者: Y. Araki;A. Andoh;J. Takizawa;W. Takizawa;Y. Fujiyama

Araki Y, et al.: "The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats"Int J Mol Med. 12. 125-129 (2003)

Araki Y 等人：“自由基清除剂依达拉奉可抑制实验性葡聚糖硫酸钠诱导的大鼠结肠炎”Int J Mol Med。

Araki Y, et al.: "The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats"Int J Mol Med. 12. 121-124 (2003)

Araki Y 等人：“自由基清除剂依达拉奉可抑制大鼠实验性十二指肠闭环诱发的急性胰腺炎”Int J Mol Med。

Araki Y, et al.: "The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and Caco-2"Oncol Rep. 10. 1931-1936 (2003)

Araki Y 等人：“肠道细胞系 IEC-6 和 Caco-2 中疏水性胆汁酸的细胞毒性通过更多亲水性胆汁酸得到改善”Oncol Rep. 10. 1931-1936 (2003)