权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The role of matrix metalloproteinase on angiogenesis and ventricular remodeling after acute myocardial infarction

基质金属蛋白酶对急性心肌梗死后血管生成和心室重塑的作用

基本信息

批准号：
15590713
负责人：
MATSUNAGA Toshiro
金额：
$ 1.92万
依托单位：
Hirosaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

We hypothesized that matrix metalloproteinases (MMP) were important for angiogenesis at early phase and ventricular remodeling at late phase after acute myocardial infarction (AMI). To clarify it, we observed the effects of MMP inhibitor on ventricular remodeling for 4 weeks after the onset of AMI in rat model. Continuous MMP inhibitor treatment (0-4 weeks) was most effective against ventricular function and remodeling after AMI compared with groups of only use for 1 week after the onset of AMI (0-1 week) and the starting after 1 week from the onset of AMI (1-4 week). Next, we examined the role of oxidative stress on MMP activity in humans. Pericardial level of MMP activity was correlated with pericardial level of 8-isoprostane, a biochemical marker of oxidative stress, and left ventricular end-diastolic volume index (LVEDVI) (European Heart Journal 2003). We also examined whether circulating MMP activity can predict LV remodeling after AMI in humans. Changes in both LVEDVI and end-systolic volume index (LVESVI) from 2 weeks to 6 months were greater in high MMP activity group than those in low activity group. Moreover, circulating level of MMP activity was positively correlated with changes in LVEDVI and LVESVI from 2 weeks to 6 months (International Journal of Cardiology).

我们推测基质金属蛋白酶（MMP）在急性心肌梗死（AMI）后早期血管新生和晚期心室重构中起重要作用。为了阐明这一点，我们观察了MMP抑制剂对大鼠AMI模型发病后4周心室重构的影响。连续MMP抑制剂治疗（0-4周）对AMI后心室功能和重塑最有效，与AMI发作后1周（0-1周）和AMI发作后1周（1-4周）开始使用MMP抑制剂的组相比。接下来，我们研究了氧化应激对人类MMP活性的作用。MMP活性的心包水平与氧化应激的生化标志物8-异前列烷的心包水平和左心室舒张末期容积指数（LVEDVI）相关（European Heart Journal 2003）。我们还研究了循环MMP活性是否可以预测人类AMI后左室重构。高MMP活性组2周~ 6个月的LVEDVI和收缩末期容积指数（LVESVI）变化均大于低MMP活性组。此外，MMP活性的循环水平与2周至6个月的LVEDVI和LVESVI的变化正相关（International Journal of Cardiology）。