A role of anandamide in the development of acute lung injury

我们研究了双胺在绵羊急性肺损伤中的作用。我们准备了清醒的绵羊进行血管监测和肺淋巴平衡。基线稳定超过2小时后静脉滴注阿南达胺5 mg。每30min测量一次肺动脉压、体动脉压、心输出量和肺淋巴流量。输注阿南达胺后，这些参数无明显变化。根据这一结果，在绵羊急性肺损伤的病理生理过程中，烷胺似乎是独立的。应该有必要检查安非他明的剂量反应。

We examined the role of anandamide in the acute lung injury in sheep. We prepared awake sheep with vascular monitoring and lung lymph balance. 5 mg of anandamide was infused intravenously after stable baseline over 2 hours. Pulmonary and systemic artery pressure, cardiac output and lung lymph flow were measured every 30 min. After the infusion of anandamide, there were no significant changes in these parameters. Based on the findings, anandmide seems to be independent in the pathophysiology in acute lung injury in sheep. It should be necessary to examine the dose response of anandmide.