A role of anandamide in the development of acute lung injury

我们研究了阿南德胺在绵羊急性肺损伤中的作用。我们准备了醒羊血管监测和肺淋巴平衡。稳定基线2小时后静脉滴注5mg阿南达胺。每30 min测量一次肺动脉和全身动脉压、心输出量和肺淋巴流量。注射阿南多巴胺后，这些参数均无明显变化。基于这些发现，阿南胺似乎在绵羊急性肺损伤的病理生理中是独立的。有必要检查阿南胺的剂量反应。

We examined the role of anandamide in the acute lung injury in sheep. We prepared awake sheep with vascular monitoring and lung lymph balance. 5 mg of anandamide was infused intravenously after stable baseline over 2 hours. Pulmonary and systemic artery pressure, cardiac output and lung lymph flow were measured every 30 min. After the infusion of anandamide, there were no significant changes in these parameters. Based on the findings, anandmide seems to be independent in the pathophysiology in acute lung injury in sheep. It should be necessary to examine the dose response of anandmide.