A role of anandamide in the development of acute lung injury

anandamide 在急性肺损伤发展中的作用

• 批准号: 15590801
• 负责人: KOIZUMI Tomonobu
• 金额: $ 2.18万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590801/
• 关键词: anadamide; endotoxin; lung injury; polymixin B; sheep

We examined the role of anandamide in the acute lung injury in sheep. We prepared awake sheep with vascular monitoring and lung lymph balance. 5 mg of anandamide was infused intravenously after stable baseline over 2 hours. Pulmonary and systemic artery pressure, cardiac output and lung lymph flow were measured every 30 min. After the infusion of anandamide, there were no significant changes in these parameters. Based on the findings, anandmide seems to be independent in the pathophysiology in acute lung injury in sheep. It should be necessary to examine the dose response of anandmide.

我们研究了花生四烯酸在绵羊急性肺损伤中的作用。我们准备了清醒的羊与血管监测和肺淋巴平衡。在稳定基线后2小时内静脉输注5 mg大麻素。每30分钟测量一次肺动脉压、体动脉压、心输出量和肺淋巴流量。根据这些发现，anandmide似乎是独立的病理生理在绵羊急性肺损伤。有必要检查anandmide的剂量反应。

项目成果

JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats

JTE-607 是一种细胞因子释放阻滞剂，可减轻大鼠酸吸入引起的肺损伤

• 发表时间: 2004
• 期刊: Eur J Pharmacol 488
• 作者: jian MY;Koizumi T 他
• 通讯作者: Koizumi T 他

Contribution of nitric oxide to adaptation of tibetan sheep to high altitude

• DOI: 10.1016/j.resp.2003.11.005
• 发表时间: 2004-05-20
• 期刊: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
• 影响因子: 2.3
• 作者: Koizumi, T;Ruan, ZH;Wang, XQ
• 通讯作者: Wang, XQ

Primary malignant lymphoma in the posterior mediastinum

后纵隔原发性恶性淋巴瘤

• 发表时间: 2004
• 期刊: Respiration 71
• 作者: Takamizawa A;Koizumi T 他
• 通讯作者: Koizumi T 他

Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized

特异性诱导型一氧化氮合酶抑制剂ONO1714对非麻醉内毒素血症期间肺淋巴滤过和气体交换的影响

• 发表时间: 2004
• 期刊: Anesthesiology 101
• 作者: Koizumi T;他
• 通讯作者: 他

Ogasawara H, et al.: "Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep"J Cardiovasc Pharmacol. 42. 521-526 (2003)

Ogasawara H 等人：“选择性一氧化氮合酶抑制剂对内毒素诱导的绵羊缺氧性肺血管收缩改变的影响”J Cardiovasc Pharmacol。