Development of diagnostic system for cognitive impairments in Parkinson's Disease

帕金森病认知障碍诊断系统的开发

• 批准号: 15590910
• 负责人: KAWAMURA Mitsuru
• 金额: $ 2.18万
• 依托单位: Showa University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590910/
• 关键词: Recognition of facial expressions; Cognition of Emotion; Inference of mental state; Social decision-making; Event-related potentials; dipole-tracing; Basal ganglia; Amygdala; 手続き記憶; 社会的意志決定; 縦断的研究

Previous studies showed that cognitive functions could be impaired in patients with Parkinson's disease (PD). However, only cognitive impairments concerning executive functions and memory (procedural memory) were reported so far. In the present study, we examined whether or not PD patients have cognitive impairments other than those in the above, using behavior analysis and EEG (event-related potentials : ERP). The following results were obtained. (1) Our previous study showed that recognition of specific facial expressions (fear and disgust) is impaired in PD patients (Kan et al.2002). Supporting this finding, our recent study using ERP showed uniqueness of facial recognition in PD patients. The ERP study using dipole-tracing technique indicated that the amygdala and the pre-motor cortex were not active during the facial expression recognition task, whereas these areas were active in the normal control. The result suggests that the amygdala could be damaged in PD patients, as well as the basal ganglia (Yoshimura et al.2005). (2) Recently, the tasks concerning "theory of mind" and "social decision-making" are used to assess the frontal-lobe functions. Since it was hypothesized that the frontal lobe would be dysfunctioning in PD patients, we examined how PD patients would perform those tasks. The results showed that PD patients performed poorly in a "theory of mind" task in which they were asked to infer the thoughts/feelings of others, and that social decision-making was also impaired in PD patients (Oheda et al, in preparation).In conclusion, the present study demonstrated that PD patients have deficits in recognition of facial expressions and in social cognition, as well as deficits in executive functions and procedural memory. In addition, the present study provided us a diagnostic tool by which we can examine clinical symptoms caused by the brain damage in the areas other than the basal ganglia, in PD patients.

以往的研究表明，帕金森病（PD）患者的认知功能可能受损。然而，到目前为止，仅报告了有关执行功能和记忆（程序性记忆）的认知障碍。在本研究中，我们检查是否PD患者有认知功能障碍以外的上述，使用行为分析和脑电图（事件相关电位：ERP）。获得了以下结果。(1)我们之前的研究表明，PD患者对特定面部表情（恐惧和厌恶）的识别受损（Kan et al.2002）。支持这一发现，我们最近的研究使用ERP显示PD患者的面部识别的独特性。采用偶极子追踪技术的ERP研究表明，杏仁核和前运动皮层在面部表情识别任务中是不活跃的，而在正常对照组中，这些区域是活跃的。结果表明，PD患者的杏仁核以及基底神经节可能受损（Yoshimura et al.2005）。(2)近年来，有关“心理理论”和“社会决策”的任务被用来评估额叶功能。由于假设PD患者的额叶功能障碍，我们研究了PD患者如何执行这些任务。结果表明，PD患者在“心理理论”任务中表现不佳，在该任务中，他们被要求推断他人的想法/感受，并且PD患者的社会决策也受损（Oheda等，准备中）。总之，本研究表明PD患者在面部表情识别和社会认知方面存在缺陷，以及执行功能和程序记忆的缺陷。此外，本研究为我们提供了一个诊断工具，我们可以检查临床症状所造成的脑损害的其他领域的基底节，在PD患者。

项目成果

Right unilateral jargonagraphia as a symptom of callosal disconnection.

右侧单侧术语书写障碍是胼胝体断开的症状。

• 期刊: Cortex (In press)
• 作者: Ihori N;Murayama J;Mimura M;Miyazawa Y;Kawamura M
• 通讯作者: Kawamura M

Midorikawa A.: "Musical Alexia for Rhythm Notation : A Discrepancy Between Pitch and Rhythm"Neurocase. 9. 232-238 (2003)

Midorikawa A.：“节奏符号的音乐亚历克西娅：音高和节奏之间的差异”Neurocase。

Right unilateral jargonagraphia as a symptom of callosal disconnection

右侧单侧术语书写障碍是胼胝体断开的症状

• 期刊: Cortex (in press)
• 作者: Ihori N;Murayama J;Mimura M;Miyazawa Y;Kawamura M
• 通讯作者: Kawamura M

An autopsied case of Sjogren's syndrome with massive necrotic and demyelinating lesions of the cerebellar white matter

干燥综合征尸检一例，伴有小脑白质大面积坏死和脱髓鞘病变

• 发表时间: 2004
• 期刊: Journal of the Neurological Sciences 225(1-2)
• 作者: Ichikawa H;Ishihara K;Fujimoto R;Katou T;Arai M;Kawamura M;Nakano I
• 通讯作者: Nakano I

菅 弥生: "扁桃体病変例における感情認知"高次脳機能研究. 23・2. 160-167 (2003)

菅义伟：“杏仁核损伤病例中的情绪识别”《高等脑功能研究》23・2（2003）。