Development of noninvasive prenatal diagnosis by using maternal blood

点击翻译按钮获取中文摘要

Circulating fetal DNA in maternal plasma can be used for both fetal genetic testing and evaluation of complications of pregnancy. As a prenatal genetic test, the greatest feature of this approach is the lack of risk. This approach was applied to the diagnosis of fetal gender, fetal RhD blood type, and fetal single-gene-disorders. However, this plasma DNA approach only allows examination of disorders where the gene of interest is present in the fetal genome but absent from maternal DNA. Since the majority of fetal DNA probably originates from villous trophoblasts, concentrations can be used for the evaluation of damage to trophoblasts, particularly in the pathological complications of pregnancy, such as pre-eclampsia, invasive placenta, hyperemesis gravidarum, and trisomy 21. Fetal DNA in the plasma of pregnant women thus offers a new source of data that can be used in various clinical settings.