Prediction and prevention of preeclampsia

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We investigated the influence of maternal smoking on the early placental expression of genes related to angiogenesis and oxidative stress. As a result, we revealed that VEGFA placental expression was higher in smoking women at 10-11 weeks of gestation. Increased VEGFA expression in the early stages of pregnancy in smoking women might contribute to the decreased risk of developing preeclampsia.Next, we investigated the benefit of antioxidant supplementation in a cohort of women with low antioxidant status.Pregnant women who had low antioxidant status treated with either antioxidants or control diets daily from 8-12 weeks. 110 women were enrolled, randomly assigned to the supplementation (n = 52) and control group (n = 58). There were significant differences (P=0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% and 14.5%, respectively). We revealed supplementation of antioxidants during early gestation might reduce the risk of pre-eclampsia.