THE SEARCH FOR CANDIDATE GENES OF SCHIZOPHRENIA IN SERIAL ANALYSIS OF GENE EXPRESION (SAGE)

苯环己哌啶（PCP）注射的动物被认为是药物依赖和精神分裂症的模型。为了确定与这些疾病相关的基因，我们使用了一系列的基因表达分析，以确定基因表达谱在啮齿动物的大脑皮层分离后1小时，腹膜内注射生理盐水或PCP（10毫克/公斤）。本研究共鉴定了215个PCP反应性标签，并收集了PCP文库中显著上调或下调的基因数据。70例日本精神分裂症患者的DNA分析显示，在101例日本对照组中，甲状腺素运载蛋白多态性的发生率没有显着差异。但是，我们的SAGE数据可能包含与精神分裂症和/或药物相关疾病有关的未知基因。

Phencyclidine (PCP)-injected animals are considered models of both drug dependence and schizophrenia. To identify genes associated with these diseases, we used serial analysis of gene expression to determine gene expression profiles in rodent cerebral cortices isolated 1 hour after intraperitoneal injection of saline or PCP (10 mg/kg). We identified 215 PCP-reactive tags and assembled data for significantly up-or down-regulated genes.Transthyretin (TTR) up-regulated in PCP library, is a kind of thyroid hormone-binding plasma proteins. DNA analysis of the 70 Japanese schizophrenic subjects revealed that the incidence of the polymorphisms of transthyretin was not significantly different in the 101 Japanese control subjects. But, our SAGE data could contain unknown genes related to schizophrenia and/or drug-related disorders.