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Non-invasive Assessment of Fatty Liver in the Donors of Living Related Liver Transplantation Using Chemical Shift MR Imaging and MR Spectroscopy

使用化学位移 MR 成像和 MR 光谱对活体相关肝移植供者的脂肪肝进行无创评估

基本信息

批准号：
15591282
负责人：
KENGO Yoshimitsu
金额：
$ 2.18万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591282/
关键词：
fatty liver MR chemical shift MR spectroscopy living-related liver transplantation 化学シフト画像

项目摘要

<Purpose>To assess the degree of fatty liver for candidates of donor of living related liver transplantation (LRLT) using chemical shift MR imaging (CSI) and plain CT<Materials and Methods>Between 2000 and 2004, 18 donors for LRLT who were suspected to have fatty liver were examined with CSI. 13 of them also underwent plain CT. 1.5 T clinical MR unit and 1 4-detector-row multislice CT were used. CSI were obtained with 2DFALSH sequence with the parameters as follows ; TR/TE1 & TE2/FA=100 msec/2.3 & 4.1msec/70°. As for the indices of fatty liver, MR index (MRIn)=(SIip-SIop)/SIip, CT index (CTIn)=(DL-DSp) were defined, where SIip/op indicate signal intensity of the liver on in-phase and out-of phase images, and DL/Sp indicates CT values of liver and spleen. Percutaneous biopsy of the liver at the right anterior segment was performed within 10 days from MR or CT examinations. Histopathological grades (X=1-5) of fatty liver was correlated to MRIn and CTIn.<Results>Both MRIn and CTIn showed good correlation the histopathological grades (MRI=-0.126+0.071X : R2=0.695, p<.0001、CTI=25.8-8.03 X : R2=0.746, p<.0001). However, when cases were limited to mildly fatty liver (less than 30% histopathologically), MRIn showed significantly better correlation than CTIn (p<0.001).<Conclusion>As non-invasive methods to evaluate fatty liver in LRLT donor patients, both MR and CT provided useful information ; the former was shown to be useful particularly for low grade fatty liver, and the latter for high grade fatty liver. MR and CT can be used complementarily for evaluation of fatty liver in LRLT donor patients

目的应用化学位移磁共振成像(CSI)和CT平扫评价供肝脂肪肝的程度。材料与方法2000~2004年，对18例疑似脂肪肝的供肝进行了化学位移磁共振成像(CSI)检查。其中13例行CT平扫。采用1.5T临床MR机和14排多层螺旋CT扫描。用2DFALSH序列获得CSI，其参数如下：tR/TE1和TE2/FA=100毫秒/2.3和4.1毫秒/70°。对于脂肪肝指标，定义了MR指数(MRIN)=(SIIP-SIOP)/SIIP，CT指数(CTIn)=(Dl-DSPs)，其中SIIP/OP表示肝脏在同相和异相图像上的信号强度，Dl/Sp表示肝脏和脾的CT值。在MR或CT检查后10天内，在右前段进行经皮肝活检。组织病理学分级(X=1~5)与、、CTIN呈正相关(P<0.05)。结果：MRIN与CTIN与组织病理学分级有较好的相关性(MRI=-0.126+0.071X：R2=0.695，P<0.0001)。然而，当病例局限于轻度脂肪肝(组织病理学低于30%)时，MRIN的相关性明显好于CTIN(p&lt；0.001)。结论作为无创性评估供肝脂肪肝的方法，MR和CT都提供了有用的信息；前者尤其适用于低度脂肪肝，后者适用于高度脂肪肝。MR和CT可互补用于LRLT供者脂肪肝的评估