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Girdling effect by wrapped sheet around the heart in the volume-overloaded left ventricle

在容量超载的左心室中用包裹片包裹心脏产生环割效应

基本信息

批准号：
15591486
负责人：
MISAWA Yoshio
金额：
$ 1.92万
依托单位：
JICHI MEDICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

We have originally made a sheet for wrapping the failing heart. We call it "a myonet". It is wrapped around the heart to prevent it from being enlarged without the impairment of ventricular diastolic function. The key includes the material and design of the myonet. We conclude that a myonet should be made of polytetrafluoroethylene strips like a net. A polytetrafluoroethylene strip has been shown its elasticity and durability in the clinical setting. The structure should be not plane but reticular to reduce ventricular diastolic dysfunction. To assess diastolic function during wrapping, a left ventricular pressure-volume loop is obtained during an acute animal study. A chronic experimental study will be based on our previous experience showing chronic left ventricular dilatation by rapid ventricular pacing.As a clinical study, shortening of the posterior leaflet is our strategy for mitral valve replacement in patients with dilated left ventricle. A study, which analyzes left ventricular remodeling after surgery, is on-going. As the other clinical studies, we have presented some articles about clinical outcomes after valve replacement, and we have discussed electrical remodeling after mitral surgery with superior septal approach.

我们原本是做了一张纸来包裹衰竭的心脏。我们称之为“肌网”。它包裹在心脏周围，以防止心脏扩大，而不会损害心室舒张功能。关键包括肌网的材料和设计。我们的结论是，肌网应该是由聚四氟乙烯条像一个网。聚四氟乙烯条已在临床环境中显示出其弹性和耐久性。结构不应是平面的，而应是网状的，以减少心室舒张功能障碍。为了评估缠绕期间的舒张功能，在急性动物研究期间获得左心室压力-容积环。慢性实验研究将基于我们先前通过快速心室起搏显示慢性左心室扩张的经验，作为临床研究，缩短后叶是我们对左心室扩张患者进行二尖瓣置换的策略。一项分析手术后左心室重塑的研究正在进行中。与其他临床研究一样，我们介绍了一些关于瓣膜置换术后临床结局的文章，并讨论了上级间隔入路二尖瓣手术后的电重构。