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Development of a new method for measuring higher brain function - integrated measuring system by fMRI and MEG -

开发测量高级脑功能的新方法——fMRI和MEG综合测量系统——

基本信息

批准号：
15591549
负责人：
OHIRA Takayuki
金额：
$ 2.24万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591549/
关键词：
median nerve stimulation functional MRI paper-rock-scissors MEG NIRS higher brain function cerebral ischemia 補足運動野感覚運動野 fMRI MEG 統合システム

项目摘要

The aim of this study is to establish a new integrated measuring system by fMRI, MEG and NIRS for evaluation of higher brain function. First, activated BOLD signals were observed during electrostimulation on bilateral median nerves by fMRI. Distributions of activated BOLD signals were evaluated in the three conditions, no delay, 30 msec delay and 100 msec delay. As a result, the smallest activated area was observed at the primary sensory area in the 30 msec delay condition. A MEG study revealed that no waves at 76 msec were observed in the 30 msec delay condition. Second, it was evaluated how the brain functions during loss-resulting or tie-resulting pursuant paper-rock-scissors with the dominant or non-dominant hands, using a 3-tesla functional MRI in normal right-handed subjects. Interestingly, the right SMA was activated more strongly during tie-resulting pursuant paper-rock-scissors with the left hand, while the left SMA was activated more strongly during loss-resulting pursuant paper-rock-scissors with the left hand. These findings suggest that the left SMA might be associated with inhibition of stereotypical performance and monitoring of conflict in the subject's mind. Last, we evaluated changes in blood concentration of hemoglobin by NIRS in the patients with severe carotid arterial stenosis before and after surgery. Before surgery, an evident elevation of blood concentration of hemoglobin was observed at the periprimary hand motor area during hand grasp task, although it disappeared after surgery. Our study revealed that further investigation is required to clarify more detailed higher brain functions, and for the achievement of this goal, it was especially important to compare the distributions of activated brain area by between fMRI and MEG during electrostimulation on bilateral median nerves.

本研究的目的是建立一种新的功能磁共振成像、脑磁图和近红外光谱综合测量系统，用于评估高级脑功能。首先，通过功能磁共振成像在双侧正中神经电刺激过程中观察到激活的 BOLD 信号。在无延迟、30毫秒延迟和100毫秒延迟这三种条件下评估激活的BOLD信号的分布。结果，在 30 毫秒延迟条件下，在初级感觉区域观察到最小的激活区域。 MEG 研究表明，在 30 毫秒延迟条件下，没有观察到 76 毫秒的波。其次，利用正常右手受试者的 3 特斯拉功能性 MRI，评估了在惯用手或非惯用手进行“石头剪刀布”导致失败或平局时大脑的功能。有趣的是，在用左手进行剪刀布石头并导致平局时，右侧 SMA 被激活得更强烈，而在左手进行剪刀布石头导致失败时，左侧 SMA 被激活得更强烈。这些发现表明，左侧 SMA 可能与抑制刻板印象和监控受试者思想冲突有关。最后，我们通过NIRS评估了颈动脉重度狭窄患者手术前后血红蛋白浓度的变化。术前，在进行抓握任务时，观察到手部初级运动区血红蛋白浓度明显升高，但术后该现象消失。我们的研究表明，需要进一步的研究来阐明更详细的高级大脑功能，并且为了实现这一目标，比较双侧正中神经电刺激期间fMRI和MEG之间激活的大脑区域的分布尤为重要。