A trial to elucidate neural mechanism of language information processing in perceptual executive system.

阐明知觉执行系统语言信息处理神经机制的尝试。

• 批准号: 12671381
• 负责人: OHIRA Takayuki
• 金额: $ 1.6万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671381/
• 关键词: Magnetoencephalography; Functional mapping; Verbal generation; SHIRITORI paradigm; Root Mean Square; Brain Mapping; Verbal Learning; Working memory

This time we attempted to explore the relation of cognition and word expression in neural perceptual executive system. Healthy right handed 4 normal volunteer (man 2, woman 2) were participated to this study. The magnetic fields while performing capping verses (called "SHIR1TORI" in Japanese) were measured by using magnetoencephalography (MEG). Responses of control session (passive hearing of tone or viewing of flash stimuli, which were used as cue stimuli in the paradigm session) and paradigm session (mental generation of words one by one according to "SHIRITORI" manner immediately after each cue stimulus emission) were recorded, then analyzed after off-line averaging. Root mean square (RMS) of averaged magnetic fields in the paradigm session delineated its increase at some latencies as compared with control one, which latencies after flash and tone stimulus onset ranged from 380msec to 930msec and 300msec to 820msec, respectively. In addition, estimated dipoles of these latencies were located to some language-related area of left hemisphere reported conventional PET and fMRI studies, including frontal operculum, fusiform and posteroinferor temporal region.

本研究试图探讨神经知觉执行系统中认知与词语表达的关系。4名健康右利手志愿者(男2名，女2名)参加本研究。使用脑磁图(MEG)测量了进行封顶动作(日语称为SHIR1TORI)时的磁场。记录控制会话(被动听音调或观看闪光刺激，在范式会话中作为线索刺激)和范式会话(在每个线索刺激发出后立即按SHIRITORI方式逐个产生单词)的反应，离线平均后进行分析。平均磁场的均方根(RMS)显示，与对照组相比，平均磁场在一定的潜伏期内增加，闪光和音调刺激开始后的潜伏期分别为380毫秒到930毫秒和300毫秒到820毫秒。此外，据报道，这些潜伏期的估计偶极子位于常规PET和fMRI研究报告的左半球一些与语言相关的区域，包括额盖、梭形和后下颞区。

项目成果

Yosei Kaneko: "Magnetoencephalographic analysis of verbal generation and expression-related neural mechanisms using capping verses, "SHIRITORI" paradigm"Recent advances in human brain mapping. Volume 1232. 77-81 (2002)

Yosei Kaneko：“使用封顶诗句对言语生成和表达相关的神经机制进行脑磁图分析，“SHIRITORI”范式”人类大脑绘图的最新进展。

M.Niimi: "Analysis of the source in the sensory area during sef-paced finger movements"Recent advances in human brain mapping. Volume 1232. 473-478 (2002)

M.Niimi：“自节奏手指运动过程中感觉区域的来源分析”人类大脑绘图的最新进展。

Y.Kaneko, T.Ohira, M.Niimi, T.Kawase, M.Ochiai, Y.Haruta: "Magnetoencephalographic analysis of verbal generation and expression-related neural mechanisms using capping verses,"SHIRITORI" paradigm"Recent advances in human brain mapping. 1232. 77-81 (2002)

Y.Kaneko、T.Ohira、M.Niimi、T.Kawase、M.Ochiai、Y.Haruta：“使用封顶诗句对言语生成和表达相关神经机制进行脑磁图分析，“SHIRITORI”范式”人类大脑的最新进展

YOSEI Kaneko et al.: "Magnetoencephalographic analysis of verbal generation and expression-related neural mechanisms using capping versos, "SHIRITORI"paradigm"International Congress Series. 707. (2001)

YOSEI Kaneko 等人：“使用上限反面对言语生成和表达相关神经机制进行脑磁图分析，“SHIRITORI”范式”国际大会系列。

M.Niimi, T.Ohira, M.Ochiai, Y.Kaneko, T.Kawase: "Analysis of the source in the sensory area during sef-paced finger movements"Recent advances in human brain mapping. 1232. 473-478 (2002)

M.Niimi、T.Ohira、M.Ochiai、Y.Kaneko、T.Kawase：“自节奏手指运动过程中感觉区域来源的分析”人类大脑绘图的最新进展。