Prostaglandin synthesis in response to spreading depression and focal brain ischemia

点击翻译按钮获取中文摘要

Temporal and topographic profiles of cyclooxygenase-2 (COX-2) expression and prostaglandins as well as [^<123>I]iomazenil distribution during 24 hours of focal brain ischemia in rats were examined. We demonstrated that prostaglandin production as well as COX-2 expression in ischemic tissues depended on the degree and duration of the reduction in cerebral blood flow (Yokota C, et al.,2004). We also confirmed that [^<123>I]iomazenil should be a useful marker of neuronal viability using histopathological findings (Kaji T, et al.2004).COX-2 was reported to be induced in the infarcted human brain. Spreading depression (SD) is thought to play a role in this induction. Thus, we correlated the expression of SD-associat.ed genes with COX-2 production in brains after SD. We showed that the bilateral induction of expression of the S-100A9 gene in response to SD was associated with COX-2 activation (Yokota C. et al.2005).We hypothesized that SD, evoked after ischemic insult, might contribute to the process of reconstitution of neural networks via the activation of SD-associated genes as a result of COX-2 production in the hemisphere contralateral to the ischemia.