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Prostaglandin synthesis in response to spreading depression and focal brain ischemia

前列腺素合成对扩散性抑郁症和局灶性脑缺血的反应

基本信息

批准号：
15591559
负责人：
YOKOTA Chiaki
金额：
$ 2.24万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591559/
关键词：
Cyclooxygenase-2 Spreading depression Rat S100A9 JTE-522 Prostaglandin RAT Focal ischemia Environmental enrichment Neurogenesis MAPK phosphatase cyclooxygenase-2 focal ischemia rat cerebral blood flow iomazenil neuronal via

项目摘要

Temporal and topographic profiles of cyclooxygenase-2 (COX-2) expression and prostaglandins as well as [^<123>I]iomazenil distribution during 24 hours of focal brain ischemia in rats were examined. We demonstrated that prostaglandin production as well as COX-2 expression in ischemic tissues depended on the degree and duration of the reduction in cerebral blood flow (Yokota C, et al.,2004). We also confirmed that [^<123>I]iomazenil should be a useful marker of neuronal viability using histopathological findings (Kaji T, et al.2004).COX-2 was reported to be induced in the infarcted human brain. Spreading depression (SD) is thought to play a role in this induction. Thus, we correlated the expression of SD-associat.ed genes with COX-2 production in brains after SD. We showed that the bilateral induction of expression of the S-100A9 gene in response to SD was associated with COX-2 activation (Yokota C. et al.2005).We hypothesized that SD, evoked after ischemic insult, might contribute to the process of reconstitution of neural networks via the activation of SD-associated genes as a result of COX-2 production in the hemisphere contralateral to the ischemia.

检查了大鼠局灶性脑缺血24小时期间环氧合酶-2（考克斯-2）表达和前列腺素以及[^<123>I]碘马唑分布的时间和地形图。我们证明了缺血组织中前列腺素的产生以及考克斯-2的表达取决于脑血流减少的程度和持续时间（Yokota C，et al.，2004年）。我们还<123>使用组织病理学发现证实[13 I]iomazenil应该是神经元活力的有用标志物（Kaji T，et al.2004）。据报道，考克斯-2在梗塞人脑中被诱导。扩散性抑制（SD）被认为在这种诱导中起作用。因此，我们将SD相关艾德基因的表达与SD后脑中考克斯-2的产生相关联。我们发现，响应SD的S-100 A9基因表达的双侧诱导与考克斯-2激活有关（Yokota C.我们假设，在缺血损伤后诱发的SD可能有助于通过SD相关基因的激活而重建神经网络的过程，所述SD相关基因的激活是缺血对侧半球中产生考克斯-2的结果。