The study of relationship between clinical charavtelization of intrauterine growth restriction and serum levels of angiogenetic factors ; placenta growth factor and vascular endothelial growth factor.

宫内环境的恶化可能影响胎盘血管生成，进而导致胎儿宫内生长受限（IUGR）。我们检测了47例IUGR和26例子痫前期孕妇血清中胎盘生长因子（PlGF）和血管内皮生长因子（VEGF）的水平，并与101例正常孕妇进行比较。此外，7名患有抗磷脂综合征（APS）的妇女在怀孕期间血清PIGF和VEGF水平，已知抗磷脂综合征是导致IUGR和宫内胎儿死亡（IUFD）的原因。7例孕妇中3例发生宫内胎儿死亡，4例产下健康儿。在正常妊娠妇女中，PIGF浓度根据妊娠周数广泛分布。平均PIGF水平在每个五周的胎龄间隔开始增加，在第二个三个月，在26至30周达到峰值，此后下降。IUGR组和子痫前期组血清PIGF水平均显著低于正常孕妇。另一方面，IUGR与正常妊娠妇女之间以及子痫前期与正常妊娠妇女之间的VEGF水平无统计学显著差异。在3例发生IUFD的APS患者中，血清P1GF水平显著低于正常孕妇和4例分娩健康婴儿的APS患者，然后下降，直到发生IUFD。而4例APS孕妇分娩健康婴儿后，其血清P1GF水平及其在妊娠期间的变化与正常对照组一致。这些结果表明，血清PIGF水平下降可能是一个有用的预测胎儿预后不良的妇女与APS。

Deterioration of intrauterine environment may affect the placental angiogenesis, followed by intrauterine fetal growth restriction (IUGR). We therefore examined the serum levels of 2 important angiogenetic factors, placenta growth factor (PIGF) and vascular endothelial growth factor (VEGF), in 47 women with IUGR and in 26 women with preeclampsia, and they were compared with those in 101 normal healthy pregnant women. In addition, serum levels of PIGF and VEGF during pregnancy in 7 women with antiphospholipid syndrome (APS) which is known to be responsible for IUGR and intrauterine fetal death (IUFD). The 3 cases of 7 women developed intrauterine fetal death (IUFD) and 4 cases delivered healthy infants. In normal pregnant women, PIGF concentrations were widely distributed according to the number of weeks of gestation. Mean PIGF level within each five-week gestational-age interval began to increase in the second trimester, peaked at 26 to 30 weeks, and decreased thereafter. Both the serum PIGF levels in women with IUGR and in those with preeclampsia were significantly lower than in normal pregnant women. On the other hand, there were no statistically significant differences in VEGF levels between the women with IUGR and normal pregnant women, and between those with preeclampsia and normal pregnant women. In 3 women with APS who developed IUFD, serum P1GF levels were significantly lower than those in normal pregnant women as well as in 4 women with APS who delivered healthy infants, and were then decreased until IUFD had occurred. In contrast, in 4 women with APS who delivered healthy babies, serum levels of P1GF and their changes during pregnancy were consistent with normal controls. These findings suggested that the decreased serum PIGF levels could be a useful predictor for poor fetal outcome in women with APS.