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The study of relationship between clinical charavtelization of intrauterine growth restriction and serum levels of angiogenetic factors ; placenta growth factor and vascular endothelial growth factor.

宫内生长受限临床特征与血清血管生成因子水平关系的研究

基本信息

批准号：
15591738
负责人：
KANAI Makoto
金额：
$ 1.86万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Deterioration of intrauterine environment may affect the placental angiogenesis, followed by intrauterine fetal growth restriction (IUGR). We therefore examined the serum levels of 2 important angiogenetic factors, placenta growth factor (PIGF) and vascular endothelial growth factor (VEGF), in 47 women with IUGR and in 26 women with preeclampsia, and they were compared with those in 101 normal healthy pregnant women. In addition, serum levels of PIGF and VEGF during pregnancy in 7 women with antiphospholipid syndrome (APS) which is known to be responsible for IUGR and intrauterine fetal death (IUFD). The 3 cases of 7 women developed intrauterine fetal death (IUFD) and 4 cases delivered healthy infants. In normal pregnant women, PIGF concentrations were widely distributed according to the number of weeks of gestation. Mean PIGF level within each five-week gestational-age interval began to increase in the second trimester, peaked at 26 to 30 weeks, and decreased thereafter. Both the serum PIGF levels in women with IUGR and in those with preeclampsia were significantly lower than in normal pregnant women. On the other hand, there were no statistically significant differences in VEGF levels between the women with IUGR and normal pregnant women, and between those with preeclampsia and normal pregnant women. In 3 women with APS who developed IUFD, serum P1GF levels were significantly lower than those in normal pregnant women as well as in 4 women with APS who delivered healthy infants, and were then decreased until IUFD had occurred. In contrast, in 4 women with APS who delivered healthy babies, serum levels of P1GF and their changes during pregnancy were consistent with normal controls. These findings suggested that the decreased serum PIGF levels could be a useful predictor for poor fetal outcome in women with APS.

宫内环境恶化可影响胎盘血管生成，进而发生宫内胎儿生长受限（IUGR）。因此，我们检测了47例IUGR妇女和26例子痫前期妇女血清中2种重要的血管生成因子——胎盘生长因子（PIGF）和血管内皮生长因子（VEGF）的水平，并与101例正常健康孕妇进行了比较。此外，7名患有抗磷脂综合征（APS）的妇女妊娠期间血清PIGF和VEGF水平，这是已知的IUGR和宫内胎儿死亡（IUFD）的原因。7例产妇中3例发生宫内死胎（IUFD）， 4例分娩出健康婴儿。在正常孕妇中，PIGF浓度根据妊娠周数分布广泛。每5周胎龄间隔内的平均PIGF水平在妊娠中期开始升高，在26 ~ 30周达到峰值，随后下降。IUGR患者和子痫前期患者的血清PIGF水平均明显低于正常孕妇。另一方面，IUGR患者与正常孕妇、子痫前期患者与正常孕妇之间VEGF水平无统计学差异。在发生IUFD的3名APS妇女中，血清P1GF水平明显低于正常孕妇和4名生下健康婴儿的APS妇女，然后下降，直到发生IUFD。相比之下，在4名生下健康婴儿的APS妇女中，血清P1GF水平及其在怀孕期间的变化与正常对照一致。这些发现表明，血清PIGF水平降低可能是APS妇女胎儿预后不良的有用预测指标。