The molecular mechanism for the regulation of neural stem cell proliferation in Drosophila
The molecular mechanism for the regulation of neural stem cell proliferation in Drosophila
果蝇神经干细胞增殖调控的分子机制
批准号：
23770262
负责人：
KANAI Makoto
金额：
$2.91万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
中文摘要
翻译
干细胞在很大程度上是由邻近的组织和细胞（称为小生境）定义的。为了确定神经胶质细胞生态位对神经干细胞增殖的贡献，我使用果蝇成神经细胞作为模型，发现神经胶质细胞和成神经细胞是物理接触的，它们相互作用以调节成神经细胞的增殖，并且在每个细胞表面上相互表达不同的分子。
英文摘要
Stemness is largely defined by neighboring tissues and cells called niche. To determine the contribution of glial cell niche for the proliferation of neural stem cell, I used Drosophila neuroblast as a model and found that glial cells and neuroblasts are in physical contact, on which they interact to regulate neuroblast proliferation with the distinct molecules that are mutually expressed on the each cell surface.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI：
10.1074/jbc.m110.208082
发表时间：
2011-05-13
期刊：
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子：
4.8
作者：
[Dejima, Katsufumi, Kanai, Makoto I., Nakato, Hiroshi]
通讯作者：
Nakato, Hiroshi
Research on the new system of gynecotocological care by cooperation in regional medical institutions and support to reinstatement of women doctors
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批准号：22590461
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.25万
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财政年份：2010
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负责人：KANAI Makoto
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依托单位：
The study of relationship between clinical charavtelization of intrauterine growth restriction and serum levels of angiogenetic factors ; placenta growth factor and vascular endothelial growth factor.
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批准号：15591738
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$1.86万
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财政年份：2003
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负责人：KANAI Makoto
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依托单位：
海外基金
