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Basic and clinical research for prevention of carcinogenesis aiming at extinction of head and neck squamous cell carcinoma.

以消灭头颈部鳞状细胞癌为目标的预防癌变的基础和临床研究。

基本信息

批准号：
15591792
负责人：
SHIGA Kiyoto
金额：
$ 2.24万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591792/
关键词：
Head and Neck Cance squamous cell carcinoma LOH Head and neck cancer etiology 遺伝子変異遺伝子多型性

项目摘要

Head and neck squamous cell carcinomas (HNSCC) manifest various clinical behaviors according to their origin, i.e., each part of the head and neck mucosa. However, differences of genetic factors involved in the carcinogenesis of head and neck squamous cell carcinoma (HNSCC) in each part of the head and neck have not yet been sufficient for study and evaluation. Three hundred and two samples of HNSCC were used to determine the allelic loss of certain areas of the genome, i.e., 3p21, 9p21 and 17p13, and to examine whether genetic factors are correlated with the tissue specificity of HNSCC and influence the clinical features of the patients. When loss of heterozygosity (LOH) at 3p21, 9p21 and 17p13 were examined, LOH was detected in 54.5%, 57.4% and 57.1% of the informative cases, respectively. The frequencies of LOH in hypopharyngeal and in laryngeal cancer were significantly higher than that in oral cancer. There were significant correlations between 3p21 LOH and lymph node involvement and 17p13 LOH and tumor size, resulting in the positive implication of clinical stage of the patients. These results indicate that not only the function of the tumor suppressor genes were different among these HNSCC in different regions but also that allelic loss plays a key role in the acquisition of malignant phenotype of the tumor.On the other hand, patients who had LOH positive cancer significantly had the poorer prognosis than those who had LOH negative tumor, indicating that allelic loss has a key role in acquisition of the malignant phenotype of the tumor to show the poorer prognosis of the patients who have the LOH positive tumor.

头颈部鳞状细胞癌（HNSCC）根据其起源表现出各种临床行为，即，头部和颈部粘膜的每一部分。然而，在头颈部各部位参与头颈部鳞状细胞癌（HNSCC）癌变的遗传因素的差异尚未得到充分的研究和评价。使用302个HNSCC样品来确定基因组的某些区域的等位基因丢失，即，3p21、9p21和17p13基因的表达，并探讨遗传因素是否与HNSCC的组织特异性相关及影响患者的临床特征。3p21、9p21和17p13位点杂合性缺失（洛）检出率分别为54.5%、57.4%和57.1%。下咽癌和喉癌的洛缺失频率显著高于口腔癌。3 p21洛缺失与淋巴结转移、17 p13洛缺失与肿瘤大小相关，对临床分期有积极意义。这些结果表明，不同地区的HNSCC中抑癌基因的功能存在差异，等位基因的丢失在肿瘤恶性表型的获得中起着重要作用，而洛阳性患者的预后明显低于洛阴性患者，表明等位基因丢失在肿瘤恶性表型的获得中具有关键作用，从而表明具有洛阳性肿瘤的患者的预后较差。