Development of the novel approaches to diagnose and treat head and neck cancer using nanotechnology

利用纳米技术开发诊断和治疗头颈癌的新方法

• 批准号: 23592520
• 负责人: SHIGA Kiyoto
• 金额: $ 3.33万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592520/
• 关键词: 頭頸部癌; 頸部リンパ節転移; 造影超音波診断; 血管新生; マイクロバブル; ナノバブル; 超音波診断; 腫瘍血管; 分子導入

It is well known that angiogenic processes in growing tumors promote increased vessel density and structural abnormalities. Lymph node metastasis of the head and neck cancer also showed this neo-vascularization features in active phase of metastasis. The purpose of this study is to evaluate the vascular density and morphology in metastatic lymph nodes by using microbubbles as ultrasound contrast-enhancing agent. On the next stage, we intend to use hybrid nanobubbles to introduce some anti-tumor agents or transformed constructs into cancer cells as drug delivery system. We developed novel image-analyzing software to analyze capillary vessels in lymph nodes of the patients. After they underwent neck dissection, all of the patients who showed contrast-enhancement in their lymph nodes had carcinoma metastases in their lymph nodes by histopathological examination. Contrast ultrasound using our software is useful to detect lymph node metastasis of the head and neck cancer.

众所周知，生长肿瘤中的血管生成过程促进血管密度增加和结构异常。头颈部肿瘤的淋巴结转移在转移活跃期也表现出这种新生血管化特征。本研究的目的是利用微泡作为超声增强剂评估转移性淋巴结的血管密度和形态。下一步，我们打算利用混合纳米气泡将一些抗肿瘤药物或转化结构物引入癌细胞中作为给药系统。我们开发了一种新的图像分析软件来分析患者淋巴结中的毛细血管。经颈部清扫术后，淋巴结造影增强的患者经组织病理学检查均为淋巴结癌转移。对比超声使用我们的软件是有用的检测淋巴结转移头颈癌。

项目成果

Contrast ultrasound to detect lymph node metastasis of head and neck cancer

超声造影检测头颈癌淋巴结转移

• 发表时间: 2013
• 作者: Daisuke Saito;Kiyoto Shiga;Katsunori Katagiri;Shun Sagai
• 通讯作者: Shun Sagai

Lymphatic mapping of mice with systemic lymphoproliferative disorder: Usefulness as an inter-lymph node metastasis model of cancer

• DOI: 10.1016/j.jim.2013.01.004
• 发表时间: 2013-03-01
• 期刊: JOURNAL OF IMMUNOLOGICAL METHODS
• 影响因子: 2.2
• 作者: Shao, Lenan;Mori, Shiro;Kodama, Tetsuya
• 通讯作者: Kodama, Tetsuya

Difficulty of the differential diagnosis of basal cell adenoma and basal cell adenocarcinoma of parotid gland by magnetic resonance imaging: case reports and literature review

磁共振成像鉴别腮腺基底细胞腺瘤与基底细胞腺癌的困难：病例报告及文献复习

• DOI: 10.1007/s11282-011-0076-7
• 发表时间: 2012
• 期刊: Oral Radiol
• 影响因子: 2.2
• 作者: Kojima I;Sakamoto M;Watanabe M,Takahashi S;Mugikura S;Shiga K;Iikubo M;Yamamura MJ;Sasano T.
• 通讯作者: Sasano T.

Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

• DOI: 10.1620/tjem.223.17
• 发表时间: 2011-01-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Ogawa, Takenori;Matsuura, Kazuto;Kobayashi, Toshimitsu
• 通讯作者: Kobayashi, Toshimitsu

Distinct Features of Second Primary Malignancies in Head and Neck Cancer Patients in Japan

• DOI: 10.1620/tjem.225.5
• 发表时间: 2011-09-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Shiga, Kiyoto;Tateda, Masaru;Kobayashi, Toshimitsu
• 通讯作者: Kobayashi, Toshimitsu