Analysis for the interphotoreceptor matrix molecules.

除小鼠外，透明质酸是光感受器间基质（IPM）的重要组成部分，它可以作为不溶性IPM中其他大分子附着的基本支架来组织基质。透明质酸结合蛋白SPACR和透明质酸之间的相互作用形成了基本的大分子支架，其中包括不溶性IPM。我们之前的研究表明，SPACR的表达随着年龄的增长而增加，与神经视网膜和视网膜色素上皮之间的粘附平行，这表明SPACR可能参与了一个介导神经视网膜和视网膜色素上皮之间粘附的系统。另一种透明质酸结合蛋白SPACRCAN和透明质酸之间的关联也参与了不溶性IPM的组织。我们将继续研究由SPACR和SPACRCAN与其他糖胺聚糖（如透明质酸、硫酸肝素和硫酸软骨素）共同产生的神经视网膜和视网膜色素上皮之间粘连的发生机制。

Except in mouse, hyaluronan is a prominent constituent of the interphotoreceptor matrix (IPM), where it may serve to organize the matrix by functioning as a basic scaffold to which other macromolecules in the insoluble IPM are attached. Interactions between SPACR, a hyaluronan binding protein, and hyaluronan serve to form the basic macromolecular scaffold, which comprises the insoluble IPM. We previously showed expression of SPACR increases with age, paralleling the adhesion between neural retina and retinal pigment epithelium, indicating that SPACR might be involved in a system that mediates adhesion between neural retina and retinal pigment epithelium. Associations between SPACRCAN, another hyaluronan binding protein, and hyaluronan are also involved m the organization of the insoluble IPM. We continue to investigate the mechanism of the occurrence of adhesion between neural retina and retinal pigment epithelium generated by SPACR and SPACRCAN in corporation with other glycosaminoglycans, such as hyaluronan, heparan sulfates, and chondroitin sulfates.