Analysis of useful molecules in interphotoreceptor matrix for retinal detachment treatment

我们之前的研究表明，鸡在光感受器间基质中SPACR的表达随着发育年龄的增加而增加，与神经视网膜和视网膜色素上皮之间的粘附平行（Zako等，2002）。由于我们假设适当使用光感受器间基质中的分子可能有助于视网膜脱离的生理恢复，我们试图分析那里的其他分子。在此，我们新鉴定了鸡光感受器间基质中的SPACRCAN。此外，通过对眼透明质酸来源的调查，我们幸运地澄清了睫状体中的five - verhy复合体。我们还发现，在鸡玻璃体和太阳弹性病的人体皮肤样本中，五维希蛋白的关键分子versican也发生了降解。综上所述，我们需要更多关于光感受器间基质分子的信息，以便利用这些分子治疗视网膜脱离。

We previously showed that chicken SPACR expression increased with developmental age in interphotoreceptor matrix, paralleling the adhesion between neural retina and retinal pigment epithelium (Zako, et al., 2002). As we hypothesized that an appropriate usage of the molecules in interphotoreceptor matrix may assist physiological recovery from retinal detachment, we tried to analyze other molecules there. Here we newly characterized chicken SPACRCAN in interphotoreceptor matrix. Furthermore, we fortunately clarified FiVerHy complex in ciliary body as a result of investigations for the origin of ocular hyaluronan. We also found the degradation of versican, a key molecule for FiVerHy, in chicken vitreous body and in human dermal samples from solar elastosis. In conclusion, we need more information about molecules in interphotoreceptor matrix to utilize these molecules for the treatment of retinal detachment.