权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Preparation of Bis-GMA monomer which does not release bisphenol A

不释放双酚A的Bis-GMA单体的制备

基本信息

批准号：
15592045
负责人：
KODAMA Yoshinori
金额：
$ 2.24万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592045/
关键词：
Bis-GMA Bisphenol A Radical

项目摘要

The aim of the present investigation was to confirm the safety of Bis-GMA monomer by removing bisphenol A (BPA) from the monomer paying attention of the radical scavenging ability of BPA.1.Radical scavenging reaction with poly(methyl methacrylate) (PMMA)The amount of radical remaining in PMMA was related to its glass transition temperature and the amount was adjustable with heating. Copolymers of methacrylate monomer with MMA was prepared to enhance the solubility of polymers in Bis-GMA. The radical scavenging reaction with these copolymers could not remove BPA completely.2.Radical scavenging reaction with precursor of radicalTaking into account the solubility in Bis-GMA, low molecular weight precursors of radical, initiator system of visible light and heat polymerization, were used. Radical forming system by heat was not able to remove BPA successfully resulting in the heat polymerization of Bis-GMA. On the other hand, radical forming system by visible light irradiation was able to control both radical scavenging reaction and polymerization by adjusting the concentration of precursor of radical and the intensity of light irradiation.3.Removal of BPA by chromatographyThe main monomer component of Bis-GMA was purified by silica gel column chromatography treatment of commercial Bis-GMA product to examine the chemical reactivity of pure Bis-GMA. The addition of a precursor of radical, copolymer or initiator into pure Bis-GMA did not produce BPA, which indicated that dental products containing Bis-GMA never exert a harmful effect such as release of BPA once BPA was removed. It was also suggested in the process of the purification of Bis-GMA that BPA can be removed by adsorbents.

本研究的目的是通过从单体中去除双酚A（BPA）来确认Bis-GMA单体的安全性，同时注意BPA的自由基清除能力。1.与聚甲基丙烯酸甲酯（PMMA）的自由基清除反应PMMA中残留的自由基的量与其玻璃化转变温度有关，并且其量可以通过加热来调节。制备了甲基丙烯酸酯单体与MMA的共聚物以提高聚合物在Bis-GMA中的溶解性。2.自由基前体的自由基清除反应考虑到自由基前体在Bis-GMA中的溶解性，采用了低分子量的自由基前体，可见光和热聚合引发体系。热自由基形成体系不能成功地去除BPA，导致Bis-GMA的热聚合。另一方面，可见光照射自由基形成体系通过调节自由基前体的浓度和光照强度，能够同时控制自由基清除反应和聚合反应。3.色谱法去除BPA对商品化的Bis-GMA进行硅胶柱色谱纯化，考察纯Bis-GMA的化学反应活性。将自由基、共聚物或引发剂的前体添加到纯Bis-GMA中不会产生BPA，这表明含有Bis-GMA的牙科产品在去除BPA后不会产生有害影响，例如BPA的释放。在Bis-GMA的纯化过程中，BPA可以通过吸附剂去除。

项目成果

期刊论文数量（32）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dipalmitoylphosphatidylcholine (DPPC) and DPPC/cholesterol liposomes as predictors of the cytotoxicity of Bis-GMA related compounds

DOI：
10.1081/lpr-120039662
发表时间：
2004-01-01
期刊：
JOURNAL OF LIPOSOME RESEARCH
影响因子：
4.4
作者：
Fujisawa, S;Kadoma, Y;Yokoe, I
通讯作者：
Yokoe, I

Kinetic studies of the radical-scavenging activity of estrogens and antiestrogens

雌激素和抗雌激素自由基清除活性的动力学研究

DOI：
发表时间：
2004
期刊：
Anticancer Res 24
影响因子：
0
作者：
Seiichiro Fujisawa;Hiroshi Terasaka;Seiichiro Fujisawa et al.;Hiroshi Terasaka et al.;S.Fujisawa;Seiichiro Fujisawa;Seiichiro Fujisawa;Seiichiro Fujisawa
通讯作者：
Seiichiro Fujisawa

Kinetics of the radical scavenging activity of β-carotene-related compounds

β-胡萝卜素相关化合物自由基清除活性的动力学

DOI：
发表时间：
2004
期刊：
SAR and QSAR Environ Res 15
影响因子：
0
作者：
Seiichiro Fujisawa;Hiroshi Terasaka;Seiichiro Fujisawa et al.;Hiroshi Terasaka et al.;S.Fujisawa
通讯作者：
S.Fujisawa

Cytotoxicity and apoptosis-inducing activity of bisphenol A and hydroquinone in HL-60 cells.

DOI：
发表时间：
2005-05
期刊：
Anticancer research
影响因子：
2
作者：
H. Terasaka;Y. Kadoma;H. Sakagami;S. Fujisawa
通讯作者：
H. Terasaka;Y. Kadoma;H. Sakagami;S. Fujisawa

Kinetic radical scavenging activity and cytotoxicity of 2-methoxy-and 2-t-butyl-substituted phenols and their dimmers

2-甲氧基和2-叔丁基取代酚及其二聚体的动力学自由基清除活性和细胞毒性

DOI：
发表时间：
2004
期刊：
Anticancer Res 24
影响因子：
0
作者：
Seiichiro Fujisawa;Hiroshi Terasaka;Seiichiro Fujisawa et al.;Hiroshi Terasaka et al.;S.Fujisawa;Seiichiro Fujisawa;Seiichiro Fujisawa;Seiichiro Fujisawa;S.Fujisawa et al.;Seiichiro Fujisawa et al.
通讯作者：
Seiichiro Fujisawa et al.