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Changes in the Cerebral Oxygen Environment during Psychosedation Sedation : Evaluation using a Near-Infrared Oxygenation Monitor

精神镇静镇静期间脑氧环境的变化：使用近红外氧合监测仪进行评估

基本信息

批准号：
15592129
负责人：
SHINOHE Yutaka
金额：
$ 1.79万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592129/
关键词：
Near-Infrared Oxygenation Monitor Psychosedation Cerebral Oxygen clinical dentistry

项目摘要

We investigated the change of the intracerebral oxygen environment during inhalation sedation with nitrous oxide(I) and intravenously injected with abirritants (Midazolam : MD- ; 0.03mg/kg,0.05mg/kg, 0.07mg/kg group, Propofol : PRF- ; 1〜3 mg/kg/hrgroup) (II) using a near-infrared oxygen monitor (NIRO).ResultsI. 1.In both groups, SBP, DBP and HR did not change significantly throughout the experiment.2. In both groups, ETCO_2 increased gradually and significantly by the room air inhalation after a mixed-gas inhalation and there was also a significant difference between the two groups.3. TCPO_2 showed a trend that decreases gradually by the room air inhalation after a mixed-gas inhalation but there was no significant difference between the tow groups.4. HbO_2 had a significant fall by room air inhalation after a mixed-gas inhalation in N2O group and there was also a significant difference between the two groups.5. Δ Cytaa3 did not change significantly throughout the experiment in both gro … More ups, and there was no significant difference between the two groups.II. 1. ETCO_2 and TCPCO_2 increased gradually under administration. After administration was halted, ETCO_2 and TCPCO_2began to decrease promptly and recovered to the original status after 10 minutes. 2. SpO_2 and TCPO_2 decreased gradually under administration. 3. HbO_2 increased gradually from 5 to 17 minutes and then decreased gradually from 18 to 38 minutes. 4. Δ Cytaa3 did not change significantly throughout the experiment.ConclusionIn conclusion, during and after nitrous oxide inhalation sedation and during and after intravenous sedation in clinical dentistry, although the oxygen content in blood fell, a satisfactory intracerebral oxygen environment was maintained.Therefore, the results of this study suggest that the partial pressure of oxygen in arterial blood will not fall from change of SpO_2 and TcPO_2, but cerebral partial pressure of oxygen falls due to the significant fall of HbO2 following inhalation of the room air after 30% of nitrous oxide inhalation. However it is believed that hypoxia of cerebral tissue does not occur from the change of Δ Cytaa3. Less

采用近红外氧监测仪（NIRO）观察吸入氧化亚氮(I)和静脉注射消毒剂（咪达唑仑：MD-； 0.03mg/kg、0.05mg/kg、0.07mg/kg组，异丙酚：PRF-； 1 ~ 3mg/kg /hr组）（II）时脑内氧环境的变化。1.两组患者收缩压、舒张压和心率在整个实验过程中均无明显变化。两组患者在混合气体吸入后，随室内空气吸入，ETCO_2逐渐显著升高，两组间差异也有统计学意义。混合气体吸入后，TCPO_2随室内空气吸入有逐渐降低的趋势，但两组间差异无统计学意义。N2O组混合气体吸入后HbO_2明显下降，两组间差异也有统计学意义。Δ Cytaa3在整个实验过程中在两组中均无明显变化…More ups，两组间无显著差异。1. ETCO_2和TCPCO_2在给药后逐渐升高。停药后，ETCO_2和tcpco_2迅速下降，10分钟后恢复原状。2. SpO_2和TCPO_2逐渐降低。3. HbO_2在5 ~ 17 min逐渐升高，在18 ~ 38 min逐渐降低。4. Δ Cytaa3在整个实验过程中没有明显变化。结论临床牙科在氧化亚氮吸入镇静期间及镇静后、静脉镇静期间及镇静后，虽然血氧含量下降，但维持了满意的脑内氧环境。因此，本研究结果表明，动脉血氧分压不会因SpO_2和TcPO_2的变化而下降，但脑氧分压下降是由于吸入30%氧化亚氮后吸入室内空气后HbO2显著下降。然而，认为脑组织缺氧不是由Δ Cytaa3的改变引起的。少