Studies on mechanisms of controlling the extracellular matrix molecules in periodontal tissue regeneration and dental ankylosis

细胞外基质分子在牙周组织再生及牙体强直中的调控机制研究

基本信息

  • 批准号:
    15592195
  • 负责人:
  • 金额:
    $ 1.92万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2005
  • 项目状态:
    已结题

项目摘要

I.Effect of cryopreservation on tooth transplantationRat molars were cryopreserved for a night before transplantation into the back subcutaneous tissue. Then the teeth were histologically examined. Results showed that cryopreservation elongated the period of periodontal regeneration, however the process of the regeneration in cryopreserved group was similar as the control non-cryopreserved group.II.Changes of the alveolar bone in the ovariectomized ratThe changes of three dimensional structure in alveolar bone of ovariectomized rats were examined by micro-CT. Results showed that significant bone loss in the alveolar bone that contain bone marrow, while no significant difference in the amount of alveolar bone that did not contain bone marrow, suggesting bone loss in postmenopausal osteoporosis occurs mainly at the endosteal surface in mandible.III.Calcified matrix formation around the hydroxyapatite placed in tooth socketThe hidroxyapatite particles were placed with/without enamel matrix protein in tooth sockets and histologically examined. Results showed that the amount of newly formed bone in the socket was not different in both group. However, a thin layer of calcified matrix was observed around the hydroxyapatite placed with enamel matrix protein. Furthermore, the collagen fibers were inserted into the thin matrix layer, suggesting enamel matrix protein has potential to promote the regeneration of cementum like and periodontal ligament like structures around hydroxyapatite.
一、低温保存对牙齿移植的影响将大鼠磨牙低温保存一夜后移植到背部皮下组织中。然后对牙齿进行组织学检查。结果表明,冷冻保存延长了牙周组织的再生时间,但冷冻保存组的牙周组织再生过程与对照组相似。II.去卵巢大鼠牙槽骨的变化采用micro-CT观察去卵巢大鼠牙槽骨三维结构的变化。结果显示,含骨髓的牙槽骨骨量丢失明显,而不含骨髓的牙槽骨骨量无明显差异,提示绝经后骨质疏松症的骨丢失主要发生在下颌骨的骨内膜表面。III.牙槽中放置的羟基磷灰石周围的钙化基质形成羟基磷灰石颗粒与/无釉基质蛋白在牙槽和组织学检查。结果显示,两组牙槽窝内新骨形成量无差异。但在加入釉质基质蛋白的羟基磷灰石周围可见一薄层钙化基质。此外,胶原纤维插入到薄的基质层中,表明釉质基质蛋白具有促进羟基磷灰石周围牙骨质样和牙周膜样结构再生的潜力。

项目成果

期刊论文数量(36)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Induction of fibulin-5 gene is regulated by tropoelastin gene, and correlated with tropoelastin accumulation in vitro
fibulin-5基因的诱导受弹性蛋白原基因调节,并与体外弹性蛋白原积累相关
Immunolocalization of receptor activator of nuclear factor‐κB ligand (RANKL) and osteoprotegerin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice
  • DOI:
    10.1111/j.1469-7580.2005.00466.x
  • 发表时间:
    2005-10
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Y. Sakakura;E. Tsuruga;K. Irie;Y. Hosokawa;Hiroaki Nakamura;T. Yajima
  • 通讯作者:
    Y. Sakakura;E. Tsuruga;K. Irie;Y. Hosokawa;Hiroaki Nakamura;T. Yajima
Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit hihg-turnover osteoporosis.
过度表达巨噬细胞迁移抑制因子(MIF)的转基因小鼠表现出高周转性骨质疏松症。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Onodera S;Sasaki S;Ohshima S;Amizuka N;Li M;Udagawa N;Irie K;Nishihira J;Koyama Y;Shiraishi A;Tohyam H;Yasuda K
  • 通讯作者:
    Yasuda K
Microfibril-associated glycoprotein-1 and fibrillin-2 are associated with tropoelastin deposition in vitro
生体膜模倣傾斜機能アパタイトの生体内吸収特性
模拟生物膜功能分级磷灰石的生物吸收特性
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    佐々木智也;村田勝;赤澤敏之;入江一元;田崎純一;有末眞
  • 通讯作者:
    有末眞
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IRIE Kazuharu其他文献

IRIE Kazuharu的其他文献

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{{ truncateString('IRIE Kazuharu', 18)}}的其他基金

Elucidation of odontoblast differentiation factors by fate mapping analysis and its application to dentin regeneration therapy
命运图谱分析阐明成牙本质细胞分化因子及其在牙本质再生治疗中的应用
  • 批准号:
    18K09641
  • 财政年份:
    2018
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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