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International standardization project for the clinico-pathological diagnosis of IgA Nephropathy : Development of pathology database with clinical correlations

IgA 肾病临床病理诊断国际标准化项目：开发具有临床相关性的病理数据库

基本信息

批准号：
17590323
负责人：
JOH Kensuke
金额：
$ 2.24万
依托单位：
Chiba-East National Hospital, Clinical Research Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

1. Revision plan of the clinico-pathological classification of IgA Nephropathy (3 rd edition by Ministry of Health, Labour and Welfare / Japanese society of Nephrology)We devised a method to compile clinico-pathological information into a database and reviewed how we can apply the database to histological classification. After having got approval of an ethic committee, 643 cases of kidney biopsy material of IgA nephropathy (IgAN) (adult 529 cases, child 114 cases) were collected from 13 university hospital and 21 kidney network institutions of National Hospital Organization. The risk factors in the histological lesions of IgAN for proteinuric progression (PUP) as well as renal functional impairment (RFI) in the patients without steroid therapy (non-ST group) was analyzed statistically, and compared the data of non-ST group with those of the group with ST (ST group), so that the histological lesions getting the effectiveness of ST could be elucidated. In addition, equations predicting probability of the prognoses was produced, by which an applicability of ST for each patient could be judged.2. Activity for an international consensus classification for IgA nephropathyA collaboration with 14 nephrologists and 13 renal pathologists in the world was planed for an international standardization of pathological diagnosis of IgAN. Kidney biopsy materials of 300 cases (adult 250 cases, child 50 cases) were collected from North America, Asia, and Europe. We diagnosed them individually and gave a reproducibility of the quantitative histopathological diagnosis using a common score sheet. We are making an original proposal about the classification by verification with accumulated pathological and clinical data.

1.伊加肾病临床病理分类的修订计划（厚生劳动省/日本肾脏学会第3版）我们设计了一种将临床病理信息汇编到数据库中的方法，并回顾了如何将数据库应用于组织学分类。经伦理委员会批准，收集了来自13所大学医院和21个国家医院组织肾脏网络机构的643例伊加肾病（IgAN）肾活检材料（成人529例，儿童114例）。统计分析未接受激素治疗的IgAN患者（非ST组）发生蛋白尿进展（PUP）和肾功能损害（RFI）的危险因素，并将非ST组与ST组（ST组）的数据进行比较，以阐明ST对IgAN组织学病变的有效性。此外，还建立了预测ST段抬高概率的方程，据此可判断ST段抬高对每位患者的适用性.伊加肾病国际共识分类活动计划与世界上14名肾病学家和13名肾脏病理学家合作，以实现IgA肾病病理诊断的国际标准化。收集了来自北美、亚洲和欧洲的300例肾活检材料，其中成人250例，儿童50例。我们分别对它们进行了诊断，并使用共同的评分表进行了定量组织病理学诊断的重现性。我们正在通过积累的病理和临床资料的验证，提出一个关于分类的原创性建议。