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Usefulness of acupoint stimulation as a non-pharmacological approach for prevention of diabetes mellitus.

穴位刺激作为非药物方法预防糖尿病的有用性。

基本信息

批准号：
17590564
负责人：
ISHIZAKI Naoto
金额：
$ 2.11万
依托单位：
Meiji University of Oriental Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

We investigated the effect of electroacupuncture (EA) at Zhongwan (CV12) acupoint on glucose tolerance and insulin sensitivity in both normal (SD) and diabetic (GK) rats using an intravenous glucose tolerance test (IVGTT) and a hyperinsulinemic euglycemic clamp studies. Results under various conditions including both immediate and sustained effects are as following ;1.Effect of EA applied during fasting and IVGTT periods in normal SD rats.A significant decrease in fasting blood glucose with the elevation of plasma insulin was observed by EA. Total glucose levels during the IVGTT were lower in the EA groups compared to controls, with a significantly higher level of relative insulin secretion.2.Effect of EA applied during fasting and IVGTT periods in diabetic GK rats.A significant decrease in fasting blood glucose with the elevation of plasma insulin concentration was observed by EA. Total glucose levels during the IVGTT were lower in the EA group compared to control.3.Effect of EA applied during Hyperinsulinemic euglycemic clamp in SD and GK rats.Glucose infusion rate (GIR) under a condition of hyperinsulinemic clamp was significantly increased during EA both in the SD and the GK rats.4.Sustained effect of EA applied repetitively prior to the IVGTT in GK rats.Both blood glucose and plasma insulin during IVGTT at three days after a series of EA repetitively applied in GK rats (3 times in 5 days) showed no significant difference compared with the controls.5.Sustained effect of EA applied repetitively prior to the Hyperinsulinemic euglycemic clamp in GK rats.GIR measured at three days after repetitive application of EA in GK rats showed no significant differences with the controls.EA significantly accelerated glucose consumption during IVGTT and hyperinsulinemic euglycemic clamp studies both in SD and GK rats. Sustained effect should be investigated in further studies.

采用静脉葡萄糖耐量试验（IVGTT）和高胰岛素正糖钳法研究电针（EA）中脘穴（CV12）对正常（SD）和糖尿病（GK）大鼠葡萄糖耐量和胰岛素敏感性的影响。包括即时效果和持续效果在内的各种条件下的结果如下：正常SD大鼠空腹和IVGTT期间应用EA的影响。EA观察到空腹血糖显著降低，血浆胰岛素升高。与对照组相比，在IVGTT期间，EA组的总葡萄糖水平较低，相对胰岛素分泌水平明显较高。糖尿病GK大鼠空腹和IVGTT期间应用EA的影响。EA观察到空腹血糖随血浆胰岛素浓度升高而显著降低。与对照组相比，在IVGTT期间，EA组的总葡萄糖水平较低。EA对SD和GK大鼠高胰岛素正糖钳夹的影响。3 .高胰岛素钳夹条件下，SD大鼠和GK大鼠在EA期间的葡萄糖输注率（GIR）均显著升高。GK大鼠IVGTT前反复应用EA的持续效应。GK大鼠连续应用EA（5天3次）后，IVGTT第3天血糖和血浆胰岛素与对照组比较无显著差异。在GK大鼠高胰岛素正糖钳夹前反复应用EA的持续效果。GK大鼠重复应用EA后3天测量的GIR与对照组无显著差异。在SD和GK大鼠的IVGTT和高胰岛素正糖钳夹研究中，EA显著加速了葡萄糖消耗。持续效果有待进一步研究。