Clinical Impact of Dysadherin Expression in tissue of Pancreatic Cancer obtained by biopsy and resection.

通过活检和切除获得的胰腺癌组织中粘连蛋白表达的临床影响。

• 批准号: 17590665
• 负责人: KUBOTA Kensuke
• 金额: $ 2.24万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590665/
• 关键词: Pancreatic cancer; Dysadherin; Early diagnosis; 膵癌

In this study, we tried to investigate the clinicalpathological impact of dysadherin expression by using tissue obtained biopsy and resection from patients with pancreatic cancer, which could be an early marker for human pancreatic cancer. T Shimamura elucidated the cell motility and metastatic potential of dysadherin expression in the human pancreatic cancer cells (T Shimamura et al. Dysadherin expression facilitate cell motility and metastatic potential of human pancreatic cancer cells. Cancer Research 2004;64:6989-6995).Although, we studied this new marker in pancreatic juice contained cancer cells obtained while ERCP compared with patients of chronic pancreatitis and with autoimmune pancreatitis in 2007, it was difficult to obtain pancreatic cancer cells using endfoscopic procedure. We could' t get any useful and rewarding result.In 2008, we modified our method to take pancreatic tissue by using FNA and endoscopic biopsy from duodenal papilla. As a result, we found that the positivity rate of dysadherin is significantly higher in pancreatic tissue and tissue of duodenal papilla than that from patients with chronic pancreatitis. We conclude that the detection of dysadherin expression in human advanced pancreatic cancer in the resected tissues and biopsied specimens is useful marker.

在这项研究中，我们试图通过使用从胰腺癌患者身上获得的活检和切除组织来研究粘着蛋白表达的临床病理影响，这可能是人类胰腺癌的早期标志物。 T Shimamura 阐明了人胰腺癌细胞中 Dysadherin 表达的细胞运动和转移潜力（T Shimamura 等人 Dysadherin 表达促进人胰腺癌细胞的细胞运动和转移潜力。Cancer Research 2004；64：6989-6995）。尽管如此，我们还是在含有癌细胞的胰液中研究了这种新标记物 ERCP与2007年的慢性胰腺炎和自身免疫性胰腺炎患者相比，内窥镜手术很难获得胰腺癌细胞。我们无法得到任何有用和有价值的结果。2008年，我们修改了方法，通过FNA和十二指肠乳头内镜活检来获取胰腺组织。结果发现，胰腺组织和十二指肠乳头组织中dysadherin的阳性率显着高于慢性胰腺炎患者。我们的结论是，在人类晚期胰腺癌的切除组织和活检标本中检测粘着蛋白表达是有用的标记。

项目成果

Characterization of K-ras Gene Mutations in Association with Mucinous Hypersecretion in Intraductal Papillary- Mucinous Neoplasms

导管内乳头状粘液性肿瘤中与粘液分泌过多相关的 K-ras 基因突变的特征

• 发表时间: 2008
• 期刊: Journal of Hepatobiliary Pancreatic Surgery 15
• 作者: Noritoshi Kobayashi;Koji Fujita
• 通讯作者: Koji Fujita

Type IV collagen 7s domain is independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage.

IV型胶原蛋白7s结构域是肝硬化阶段前非酒精性脂肪性肝炎患者纤维化严重程度的独立临床标志物。

• 发表时间: 2007
• 期刊: J Gastroenterology 42
• 作者: M Yoneda;H Mawatari;K Fujuta;Kyoko Yonemitu;S Kato;H Takahashi;S Saito;H Kirikoshi;M Inamori;Y Nozaki;Y Abe;K Kubota;S Saito;T Iwasaki;Y Terauti;S Togo;A Nakajima
• 通讯作者: A Nakajima

Clinical Significance of the duodenal papilla in patients with separate ofrifices for the bile and pancreatic ducts.

胆管和胰管有不同管口的患者十二指肠乳头的临床意义。

• 发表时间: 2007
• 期刊: J Gastroenterol 42(1)
• 作者: Kubota K;Fujisawa T;Abe Y;Inamori M;Kirikoshi H;Saito S;Nakajima A
• 通讯作者: Nakajima A

Clinical Significance of Swollen Duodenal Papilla in Autoimmune Pancreatitis

自身免疫性胰腺炎十二指肠乳头肿胀的临床意义

• 期刊: Pancreas (in press)
• 作者: Kensuke Kubota;Hiroshi Iida;Toshio Fujisawa;Masami Ogawa;Masahiko Inamori;Satoru Saito;Yukio Kakuta;Hisashi Oshiro;Atushi Nakajima
• 通讯作者: Atushi Nakajima

Nuclear receptors as targets for drug development: the role of nuclear receptors during neural stem cell proliferation and differentiation.

• DOI: 10.1254/jphs.fmj04008x3
• 发表时间: 2005
• 期刊: Journal of pharmacological sciences
• 影响因子: 3.5
• 作者: K. Katayama;K. Wada;A. Nakajima;Y. Kamisaki;T. Mayumi